Long-Term Perseveration in Alzheimer’s Disease: A Case Report
The most common clinical sign of Alzheimer's disease (AD) is progressive memory loss. Presented here is a case of AD who, despite ultimate profound dementia with severe amnesia, showed retention of a perseverative response she developed during 26 encounters, over 4.5 years, with the Brown–Peter...
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| Format: | Article |
| Language: | English |
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IOS Press
2015
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| Online Access: | http://hdl.handle.net/1721.1/96240 |
| _version_ | 1826204291922132992 |
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| author | Sullivan, Edith V. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Sullivan, Edith V. |
| author_sort | Sullivan, Edith V. |
| collection | MIT |
| description | The most common clinical sign of Alzheimer's disease (AD) is progressive memory loss. Presented here is a case of AD who, despite ultimate profound dementia with severe amnesia, showed retention of a perseverative response she developed during 26 encounters, over 4.5 years, with the Brown–Peterson distractor test. From Test 9 onwards, she responded from the first distractor-filled trial with one consonant trigram, appearing in none of the seven test forms given her. At Test 26, she could not repeat heard trigrams yet faithfully responded with her perseverative trigram. The trigram, ostensibly declarative information, apparently became part and parcel of the task's procedure. Although perseveration is a form of impairment probably resulting from Alzheimer pathology involving frontal and parietal cortex, it may also reflect a form of preserved memory, albeit distorted, supported by posterior cortical regions spared in AD. |
| first_indexed | 2024-09-23T12:51:58Z |
| format | Article |
| id | mit-1721.1/96240 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:51:58Z |
| publishDate | 2015 |
| publisher | IOS Press |
| record_format | dspace |
| spelling | mit-1721.1/962402022-10-01T11:35:31Z Long-Term Perseveration in Alzheimer’s Disease: A Case Report Sullivan, Edith V. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Sullivan, Edith V. The most common clinical sign of Alzheimer's disease (AD) is progressive memory loss. Presented here is a case of AD who, despite ultimate profound dementia with severe amnesia, showed retention of a perseverative response she developed during 26 encounters, over 4.5 years, with the Brown–Peterson distractor test. From Test 9 onwards, she responded from the first distractor-filled trial with one consonant trigram, appearing in none of the seven test forms given her. At Test 26, she could not repeat heard trigrams yet faithfully responded with her perseverative trigram. The trigram, ostensibly declarative information, apparently became part and parcel of the task's procedure. Although perseveration is a form of impairment probably resulting from Alzheimer pathology involving frontal and parietal cortex, it may also reflect a form of preserved memory, albeit distorted, supported by posterior cortical regions spared in AD. National Institutes of Health (U.S.) (Grant RR 00088) National Institutes of Health (U.S.) (Grant MH 32724) National Institutes of Health (U.S.) (Grant MH 2433) National Institutes of Health (U.S.) (Grant P50-AG 05134) National Institutes of Health (U.S.) (Grant MH 40041) United States. Dept. of Veterans Affairs. Medical Research Service 2015-03-30T14:42:04Z 2015-03-30T14:42:04Z 1991 2015-03-26T13:17:01Z Article http://purl.org/eprint/type/JournalArticle 0953-4180 1875-8584 http://hdl.handle.net/1721.1/96240 Sullivan, Edith V. “Long-Term Perseveration in Alzheimer’s Disease: A Case Report,” Behavioural Neurology, vol. 4, no. 4, pp. 225-233, 1991. © 1991 Rapid Communications of Oxford Ltd en http://dx.doi.org/10.3233/BEN-1991-4402 Behavioural Neurology Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 1991 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf IOS Press Hindawi Publishing Corporation |
| spellingShingle | Sullivan, Edith V. Long-Term Perseveration in Alzheimer’s Disease: A Case Report |
| title | Long-Term Perseveration in Alzheimer’s Disease: A Case Report |
| title_full | Long-Term Perseveration in Alzheimer’s Disease: A Case Report |
| title_fullStr | Long-Term Perseveration in Alzheimer’s Disease: A Case Report |
| title_full_unstemmed | Long-Term Perseveration in Alzheimer’s Disease: A Case Report |
| title_short | Long-Term Perseveration in Alzheimer’s Disease: A Case Report |
| title_sort | long term perseveration in alzheimer s disease a case report |
| url | http://hdl.handle.net/1721.1/96240 |
| work_keys_str_mv | AT sullivanedithv longtermperseverationinalzheimersdiseaseacasereport |