Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation
Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/1721.1/96242 |
| _version_ | 1811076419759898624 |
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| author | Merok, Joshua R. Sherley, James L. |
| author2 | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
| author_facet | Massachusetts Institute of Technology. Center for Environmental Health Sciences Merok, Joshua R. Sherley, James L. |
| author_sort | Merok, Joshua R. |
| collection | MIT |
| description | Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs retain these growth kinetics in vitro, a natural kinetic barrier to SSC propagation exists. Recent discoveries showing that the tumor suppressor gene p53 can act as a regulator of asymmetric cell kinetics provide a target pathway for in vitro SSC propagation strategies. |
| first_indexed | 2024-09-23T10:21:31Z |
| format | Article |
| id | mit-1721.1/96242 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:21:31Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/962422022-09-26T17:22:53Z Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation Merok, Joshua R. Sherley, James L. Massachusetts Institute of Technology. Center for Environmental Health Sciences Merok, Joshua R. Sherley, James L. Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs retain these growth kinetics in vitro, a natural kinetic barrier to SSC propagation exists. Recent discoveries showing that the tumor suppressor gene p53 can act as a regulator of asymmetric cell kinetics provide a target pathway for in vitro SSC propagation strategies. 2015-03-30T15:08:54Z 2015-03-30T15:08:54Z 2001 2015-03-26T13:16:37Z Article http://purl.org/eprint/type/JournalArticle 1110-7243 http://hdl.handle.net/1721.1/96242 Merok, Joshua R., and James L. Sherley. “Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation.” Journal of Biomedicine and Biotechnology 1, no. 1 (2001): 25–27. © 2001 Hindawi Publishing Corporation en http://dx.doi.org/10.1155/S1110724301000067 Journal of Biomedicine and Biotechnology Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Merok, Joshua R. Sherley, James L. Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation |
| title | Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation |
| title_full | Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation |
| title_fullStr | Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation |
| title_full_unstemmed | Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation |
| title_short | Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation |
| title_sort | breaching the kinetic barrier to in vitro somatic stem cell propagation |
| url | http://hdl.handle.net/1721.1/96242 |
| work_keys_str_mv | AT merokjoshuar breachingthekineticbarriertoinvitrosomaticstemcellpropagation AT sherleyjamesl breachingthekineticbarriertoinvitrosomaticstemcellpropagation |