Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis
Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the m...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/1721.1/96247 |
| _version_ | 1826193894731153408 |
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| author | Halassa, Michael M. Dal Maschio, Marco Beltramo, Riccardo Haydon, Philip G. Benfenati, Fabio Fellin, Tommaso |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Halassa, Michael M. Dal Maschio, Marco Beltramo, Riccardo Haydon, Philip G. Benfenati, Fabio Fellin, Tommaso |
| author_sort | Halassa, Michael M. |
| collection | MIT |
| description | Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles. |
| first_indexed | 2024-09-23T09:46:59Z |
| format | Article |
| id | mit-1721.1/96247 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:46:59Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/962472022-09-26T13:40:14Z Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis Halassa, Michael M. Dal Maschio, Marco Beltramo, Riccardo Haydon, Philip G. Benfenati, Fabio Fellin, Tommaso Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Halassa, Michael M. Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles. Italy. Ministero dell'istruzione, dell'universita e della ricerca Telethon-Italy (GGP09134) 2015-03-30T16:26:11Z 2015-03-30T16:26:11Z 2010-08 2010-06 2015-03-26T09:45:45Z Article http://purl.org/eprint/type/JournalArticle 1537-744X http://hdl.handle.net/1721.1/96247 Halassa, Michael M., Marco Dal Maschio, Riccardo Beltramo, Philip G. Haydon, Fabio Benfenati, and Tommaso Fellin. “Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis.” The Scientific World JOURNAL 10 (2010): 1634–1645. en http://dx.doi.org/10.1100/tsw.2010.130 The Scientific World JOURNAL Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2010 Michael M. Halassa et al. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Halassa, Michael M. Dal Maschio, Marco Beltramo, Riccardo Haydon, Philip G. Benfenati, Fabio Fellin, Tommaso Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis |
| title | Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis |
| title_full | Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis |
| title_fullStr | Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis |
| title_full_unstemmed | Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis |
| title_short | Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis |
| title_sort | integrated brain circuits neuron astrocyte interaction in sleep related rhythmogenesis |
| url | http://hdl.handle.net/1721.1/96247 |
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