Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy

Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy

Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated malignancies. Here, we show that select microenvironments can underlie resistance to antibody-based therapy. Using a humanized model of treatment refractory B cell leukemia, we find that infilt...

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Bibliographic Details
Main Authors: Pallasch, Christian, Leskov, Ilya B., Vorholt, Daniela, Drake, Adam, Bent, Eric H., Schwamb, Janine, Iliopoulou, Bettina P., Kutsch, Nadine, van Rooijen, Nico, Frenzel, Lukas P., Wendtner, Clemens M., Heukamp, Lukas, Kreuzer, Karl Anton, Hallek, Michael, Chen, Jianzhu, Braun, Christian Joerg, Soto Feliciano, Yadira Marie, Hemann, Michael
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/96265
https://orcid.org/0000-0001-5118-8478
https://orcid.org/0000-0002-5229-8748
https://orcid.org/0000-0002-5687-6154
https://orcid.org/0000-0002-6604-2129

Internet

http://hdl.handle.net/1721.1/96265
https://orcid.org/0000-0001-5118-8478
https://orcid.org/0000-0002-5229-8748
https://orcid.org/0000-0002-5687-6154
https://orcid.org/0000-0002-6604-2129

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