Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China
Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an i...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2015
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| Online Access: | http://hdl.handle.net/1721.1/96334 https://orcid.org/0000-0002-5687-6154 |
| _version_ | 1811089714559582208 |
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| author | Wu, Aiping Su, Chunhu Wang, Dayan Peng, Yousong Liu, Mi Hua, Sha Li, Tianxian Gao, George F. Tang, Hong Chen, Jianzhu Liu, Xiufan Shu, Yuelong Peng, Daxin Jiang, Taijiao |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Wu, Aiping Su, Chunhu Wang, Dayan Peng, Yousong Liu, Mi Hua, Sha Li, Tianxian Gao, George F. Tang, Hong Chen, Jianzhu Liu, Xiufan Shu, Yuelong Peng, Daxin Jiang, Taijiao |
| author_sort | Wu, Aiping |
| collection | MIT |
| description | Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an in-depth evolutionary analysis of whole-genome sequence data of 45 H7N9 and 42 H9N2 viruses isolated from humans, poultry, and wild birds during recent influenza surveillance efforts in China. Our analysis shows that the H7N9 viruses were generated by at least two steps of sequential reassortments involving distinct H9N2 donor viruses in different hosts. The first reassortment likely occurred in wild birds and the second in domestic birds in east China in early 2012. Our study identifies the pathways for the generation of diverse H7N9 genotypes in China and highlights the importance of monitoring multiple sources for effective surveillance of potential influenza outbreaks. |
| first_indexed | 2024-09-23T14:23:33Z |
| format | Article |
| id | mit-1721.1/96334 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:23:33Z |
| publishDate | 2015 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/963342022-10-01T21:01:56Z Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China Wu, Aiping Su, Chunhu Wang, Dayan Peng, Yousong Liu, Mi Hua, Sha Li, Tianxian Gao, George F. Tang, Hong Chen, Jianzhu Liu, Xiufan Shu, Yuelong Peng, Daxin Jiang, Taijiao Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Chen, Jianzhu Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an in-depth evolutionary analysis of whole-genome sequence data of 45 H7N9 and 42 H9N2 viruses isolated from humans, poultry, and wild birds during recent influenza surveillance efforts in China. Our analysis shows that the H7N9 viruses were generated by at least two steps of sequential reassortments involving distinct H9N2 donor viruses in different hosts. The first reassortment likely occurred in wild birds and the second in domestic birds in east China in early 2012. Our study identifies the pathways for the generation of diverse H7N9 genotypes in China and highlights the importance of monitoring multiple sources for effective surveillance of potential influenza outbreaks. National Natural Science Foundation (China) (31125016) National Natural Science Foundation (China) (31371338) National Center for Biotechnology Information (U.S.) (Major National Earmark Project for Infectious Diseases, 2013ZX10004611-002) National Basic Research Program of China (973 Program) National Basic Research Program of China (973 Program, grant, 2009CB918503) National Science and Technology Major Projects (2012ZX10004214001002) Jiangsu Sheng (China) (Priority Academic Program Development of Jiangsu Higher Education Institutions) National Natural Science Foundation (China) (31100950) MIT International Science and Technology Initiatives 2015-04-02T16:45:59Z 2015-04-02T16:45:59Z 2013-10 2013-08 Article http://purl.org/eprint/type/JournalArticle 19313128 http://hdl.handle.net/1721.1/96334 Wu, Aiping, Chunhu Su, Dayan Wang, Yousong Peng, Mi Liu, Sha Hua, Tianxian Li, et al. “Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China.” Cell Host & Microbe 14, no. 4 (October 2013): 446–452. © 2013 Elsevier Inc. https://orcid.org/0000-0002-5687-6154 en_US http://dx.doi.org/10.1016/j.chom.2013.09.001 Cell Host & Microbe Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier B.V. Elsevier Open Archive |
| spellingShingle | Wu, Aiping Su, Chunhu Wang, Dayan Peng, Yousong Liu, Mi Hua, Sha Li, Tianxian Gao, George F. Tang, Hong Chen, Jianzhu Liu, Xiufan Shu, Yuelong Peng, Daxin Jiang, Taijiao Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China |
| title | Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China |
| title_full | Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China |
| title_fullStr | Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China |
| title_full_unstemmed | Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China |
| title_short | Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China |
| title_sort | sequential reassortments underlie diverse influenza h7n9 genotypes in china |
| url | http://hdl.handle.net/1721.1/96334 https://orcid.org/0000-0002-5687-6154 |
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