Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease in Collagen Fibrils
Osteogenesis imperfecta (OI) is a genetic disorder in collagen characterized by mechanically weakened tendon, fragile bones, skeletal deformities, and in severe cases, prenatal death. Although many studies have attempted to associate specific mutation types with phenotypic severity, the molecular an...
Main Authors: | Gautieri, Alfonso, Vesentini, Simone, Redaelli, Alberto, Uzel, Sebastien Guy Marcel, Buehler, Markus J |
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Other Authors: | Massachusetts Institute of Technology. Center for Computational Engineering |
Format: | Article |
Language: | en_US |
Published: |
Elsevier B.V.
2015
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Online Access: | http://hdl.handle.net/1721.1/96356 https://orcid.org/0000-0003-4540-3789 https://orcid.org/0000-0002-4173-9659 |
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