Aza-Tryptamine Substrates in Monoterpene Indole Alkaloid Biosynthesis

Biosynthetic pathways can be hijacked to yield novel compounds by introduction of novel starting materials. Here we have altered tryptamine, which serves as the starting substrate for a variety of alkaloid biosynthetic pathways, by replacing the indole with one of four aza-indole isomers. We show th...

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Bibliographic Details
Main Authors: Lee, Hyang-Yeol, Yerkes, Nancy Mary, O'Connor, Sarah Ellen
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Elsevier B.V. 2015
Online Access:http://hdl.handle.net/1721.1/96361