MicroRNAs: Target Recognition and Regulatory Functions
MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and disc...
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| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2015
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| Online Access: | http://hdl.handle.net/1721.1/96383 https://orcid.org/0000-0002-3872-2856 |
| _version_ | 1811080239250407424 |
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| author | Bartel, David |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bartel, David |
| author_sort | Bartel, David |
| collection | MIT |
| description | MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes. |
| first_indexed | 2024-09-23T11:28:02Z |
| format | Article |
| id | mit-1721.1/96383 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:28:02Z |
| publishDate | 2015 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/963832022-09-27T19:41:41Z MicroRNAs: Target Recognition and Regulatory Functions Bartel, David Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Bartel, David MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes. National Institutes of Health (U.S.) 2015-04-03T18:55:56Z 2015-04-03T18:55:56Z 2009-01 Article http://purl.org/eprint/type/JournalArticle 00928674 http://hdl.handle.net/1721.1/96383 Bartel, David P. “MicroRNAs: Target Recognition and Regulatory Functions.” Cell 136, no. 2 (January 2009): 215–233. © 2009 Elsevier Inc. https://orcid.org/0000-0002-3872-2856 en_US http://dx.doi.org/10.1016/j.cell.2009.01.002 Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier B.V. Elsevier |
| spellingShingle | Bartel, David MicroRNAs: Target Recognition and Regulatory Functions |
| title | MicroRNAs: Target Recognition and Regulatory Functions |
| title_full | MicroRNAs: Target Recognition and Regulatory Functions |
| title_fullStr | MicroRNAs: Target Recognition and Regulatory Functions |
| title_full_unstemmed | MicroRNAs: Target Recognition and Regulatory Functions |
| title_short | MicroRNAs: Target Recognition and Regulatory Functions |
| title_sort | micrornas target recognition and regulatory functions |
| url | http://hdl.handle.net/1721.1/96383 https://orcid.org/0000-0002-3872-2856 |
| work_keys_str_mv | AT barteldavid micrornastargetrecognitionandregulatoryfunctions |