Topical Developments in High-Field Dynamic Nuclear Polarization
We report our recent efforts directed at improving high-field dynamic nuclear polarization (DNP) experiments. We investigated a series of thiourea nitroxide radicals and the associated DNP enhancements ranging from ε=25 to 82, which demonstrate the impact of molecular structure on performance. We di...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2015
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| Online Access: | http://hdl.handle.net/1721.1/96402 https://orcid.org/0000-0003-1589-832X https://orcid.org/0000-0002-6708-7660 |
| _version_ | 1811097028496719872 |
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| author | Michaelis, Vladimir K. Ong, Ta-Chung Kiesewetter, Matthew K. Frantz, Derik K. Ravera, Enrico Luchinat, Claudio Walish, Joseph John Griffin, Robert Guy Swager, Timothy M |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Michaelis, Vladimir K. Ong, Ta-Chung Kiesewetter, Matthew K. Frantz, Derik K. Ravera, Enrico Luchinat, Claudio Walish, Joseph John Griffin, Robert Guy Swager, Timothy M |
| author_sort | Michaelis, Vladimir K. |
| collection | MIT |
| description | We report our recent efforts directed at improving high-field dynamic nuclear polarization (DNP) experiments. We investigated a series of thiourea nitroxide radicals and the associated DNP enhancements ranging from ε=25 to 82, which demonstrate the impact of molecular structure on performance. We directly polarized low-gamma nuclei, including [superscript 13]C, [superscript 2]H, and [superscript 17]O, by the cross effect mechanism using trityl radicals as a polarization agent. We discuss a variety of sample preparation techniques for DNP with emphasis on the benefits of methods that do not use a glass-forming cryoprotecting matrix. Lastly, we describe a corrugated waveguide for use in a 700 MHz/460 GHz DNP system that improves microwave delivery and increases enhancements up to 50%. |
| first_indexed | 2024-09-23T16:53:11Z |
| format | Article |
| id | mit-1721.1/96402 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:53:11Z |
| publishDate | 2015 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/964022022-09-29T22:09:29Z Topical Developments in High-Field Dynamic Nuclear Polarization Michaelis, Vladimir K. Ong, Ta-Chung Kiesewetter, Matthew K. Frantz, Derik K. Ravera, Enrico Luchinat, Claudio Walish, Joseph John Griffin, Robert Guy Swager, Timothy M Massachusetts Institute of Technology. Department of Chemistry Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) Griffin, Robert Guy Michaelis, Vladimir K. Ong, Ta-Chung Kiesewetter, Matthew K. Frantz, Derik K. Walish, Joseph John Swager, Timothy Manning Griffin, Robert Guy We report our recent efforts directed at improving high-field dynamic nuclear polarization (DNP) experiments. We investigated a series of thiourea nitroxide radicals and the associated DNP enhancements ranging from ε=25 to 82, which demonstrate the impact of molecular structure on performance. We directly polarized low-gamma nuclei, including [superscript 13]C, [superscript 2]H, and [superscript 17]O, by the cross effect mechanism using trityl radicals as a polarization agent. We discuss a variety of sample preparation techniques for DNP with emphasis on the benefits of methods that do not use a glass-forming cryoprotecting matrix. Lastly, we describe a corrugated waveguide for use in a 700 MHz/460 GHz DNP system that improves microwave delivery and increases enhancements up to 50%. National Institutes of Health (U.S.) (Grant EB002804) National Institutes of Health (U.S.) (Grant EB003151) National Institutes of Health (U.S.) (Grant EB002026) National Institutes of Health (U.S.) (Grant EB001960) National Institutes of Health (U.S.) (Grant EB001035) National Institutes of Health (U.S.) (Grant EB001965) National Institutes of Health (U.S.) (Grant EB004866) National Institute of General Medical Sciences (U.S.) (Grant GM095843) Natural Sciences and Engineering Research Council of Canada (Postdoctoral Fellowship) 2015-04-07T18:00:46Z 2015-04-07T18:00:46Z 2014-02 2013-10 Article http://purl.org/eprint/type/JournalArticle 00212148 1869-5868 http://hdl.handle.net/1721.1/96402 Michaelis, Vladimir K., Ta-Chung Ong, Matthew K. Kiesewetter, Derik K. Frantz, Joseph J. Walish, Enrico Ravera, Claudio Luchinat, Timothy M. Swager, and Robert G. Griffin. “Topical Developments in High-Field Dynamic Nuclear Polarization.” Isr. J. Chem. 54, no. 1–2 (February 2014): 207–221. https://orcid.org/0000-0003-1589-832X https://orcid.org/0000-0002-6708-7660 en_US http://dx.doi.org/10.1002/ijch.201300126 Israel Journal of Chemistry Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell Prof. Griffin via Erja Kajosalo |
| spellingShingle | Michaelis, Vladimir K. Ong, Ta-Chung Kiesewetter, Matthew K. Frantz, Derik K. Ravera, Enrico Luchinat, Claudio Walish, Joseph John Griffin, Robert Guy Swager, Timothy M Topical Developments in High-Field Dynamic Nuclear Polarization |
| title | Topical Developments in High-Field Dynamic Nuclear Polarization |
| title_full | Topical Developments in High-Field Dynamic Nuclear Polarization |
| title_fullStr | Topical Developments in High-Field Dynamic Nuclear Polarization |
| title_full_unstemmed | Topical Developments in High-Field Dynamic Nuclear Polarization |
| title_short | Topical Developments in High-Field Dynamic Nuclear Polarization |
| title_sort | topical developments in high field dynamic nuclear polarization |
| url | http://hdl.handle.net/1721.1/96402 https://orcid.org/0000-0003-1589-832X https://orcid.org/0000-0002-6708-7660 |
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