Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

Predicting clinical response to anticancer drugs remains a major challenge in cancer treatment. Emerging reports indicate that the tumour microenvironment and heterogeneity can limit the predictive power of current biomarker-guided strategies for chemotherapy. Here we report the engineering of perso...

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Bibliographic Details
Main Authors: Majumder, Biswanath, Baraneedharan, Ulaganathan, Thiyagarajan, Saravanan, Radhakrishnan, Padhma, Narasimhan, Harikrishna, Dhandapani, Muthu, Brijwani, Nilesh, Pinto, Dency D., Prasath, Arun, Shanthappa, Basavaraja U., Thayakumar, Allen, Surendran, Rajagopalan, Babu, Govind K., Shenoy, Ashok M., Kuriakose, Moni A., Bergthold, Guillaume, Horowitz, Peleg, Loda, Massimo, Beroukhim, Rameen, Agarwal, Shivani, Sengupta, Shiladitya, Sundaram, Mallikarjun, Majumder, Pradip K.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96406

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