The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment
Lineage-committed cells of many tissues exhibit substantial plasticity in contexts such as wound healing and tumorigenesis, but the regulation of this process is not well understood. We identified the Hippo transducer WWTR1/TAZ in a screen of transcription factors that are able to prompt lineage swi...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/96414 https://orcid.org/0000-0002-9703-1780 |
| _version_ | 1826201438863228928 |
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| author | Skibinski, Adam Breindel, Jerrica L. Prat, Aleix Smith, Elizabeth Rolfs, Andreas LaBaer, Joshua Kuperwasser, Charlotte Galvan, Patricia Gupta, Piyush |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Skibinski, Adam Breindel, Jerrica L. Prat, Aleix Smith, Elizabeth Rolfs, Andreas LaBaer, Joshua Kuperwasser, Charlotte Galvan, Patricia Gupta, Piyush |
| author_sort | Skibinski, Adam |
| collection | MIT |
| description | Lineage-committed cells of many tissues exhibit substantial plasticity in contexts such as wound healing and tumorigenesis, but the regulation of this process is not well understood. We identified the Hippo transducer WWTR1/TAZ in a screen of transcription factors that are able to prompt lineage switching of mammary epithelial cells. Forced expression of TAZ in luminal cells induces them to adopt basal characteristics, and depletion of TAZ in basal and/or myoepithelial cells leads to luminal differentiation. In human and mouse tissues, TAZ is active only in basal cells and is critical for basal cell maintenance during homeostasis. Accordingly, loss of TAZ affects mammary gland development, leading to an imbalance of luminal and basal populations as well as branching defects. Mechanistically, TAZ interacts with components of the SWI/SNF complex to modulate lineage-specific gene expression. Collectively, these findings uncover a new role for Hippo signaling in the determination of lineage identity through recruitment of chromatin-remodeling complexes. |
| first_indexed | 2024-09-23T11:51:35Z |
| format | Article |
| id | mit-1721.1/96414 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:51:35Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/964142022-09-27T22:25:58Z The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment Skibinski, Adam Breindel, Jerrica L. Prat, Aleix Smith, Elizabeth Rolfs, Andreas LaBaer, Joshua Kuperwasser, Charlotte Galvan, Patricia Gupta, Piyush Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Rolfs, Andreas Gupta, Piyush Lineage-committed cells of many tissues exhibit substantial plasticity in contexts such as wound healing and tumorigenesis, but the regulation of this process is not well understood. We identified the Hippo transducer WWTR1/TAZ in a screen of transcription factors that are able to prompt lineage switching of mammary epithelial cells. Forced expression of TAZ in luminal cells induces them to adopt basal characteristics, and depletion of TAZ in basal and/or myoepithelial cells leads to luminal differentiation. In human and mouse tissues, TAZ is active only in basal cells and is critical for basal cell maintenance during homeostasis. Accordingly, loss of TAZ affects mammary gland development, leading to an imbalance of luminal and basal populations as well as branching defects. Mechanistically, TAZ interacts with components of the SWI/SNF complex to modulate lineage-specific gene expression. Collectively, these findings uncover a new role for Hippo signaling in the determination of lineage identity through recruitment of chromatin-remodeling complexes. Breast Cancer Research Foundation Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (Grant R01HD073035) National Cancer Institute (U.S.) (Grant P01CA092644) 2015-04-07T18:50:50Z 2015-04-07T18:50:50Z 2014-03 2014-02 Article http://purl.org/eprint/type/JournalArticle 22111247 http://hdl.handle.net/1721.1/96414 Skibinski, Adam, Jerrica L. Breindel, Aleix Prat, Patricia Galvan, Elizabeth Smith, Andreas Rolfs, Piyush B. Gupta, Joshua LaBaer, and Charlotte Kuperwasser. “The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment.” Cell Reports 6, no. 6 (March 2014): 1059–1072. https://orcid.org/0000-0002-9703-1780 en_US http://dx.doi.org/10.1016/j.celrep.2014.02.038 Cell Reports Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License http://creativecommons.org/licenses/by-nc-nd/3.0/ application/pdf Elsevier Elsevier Open Access |
| spellingShingle | Skibinski, Adam Breindel, Jerrica L. Prat, Aleix Smith, Elizabeth Rolfs, Andreas LaBaer, Joshua Kuperwasser, Charlotte Galvan, Patricia Gupta, Piyush The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment |
| title | The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment |
| title_full | The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment |
| title_fullStr | The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment |
| title_full_unstemmed | The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment |
| title_short | The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment |
| title_sort | hippo transducer taz interacts with the swi snf complex to regulate breast epithelial lineage commitment |
| url | http://hdl.handle.net/1721.1/96414 https://orcid.org/0000-0002-9703-1780 |
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