Mutational heterogeneity in cancer and the search for new cancer genes

Mutational heterogeneity in cancer and the search for new cancer genes

Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched tumour–normal samples followed by mathematical analysis to identify those genes in...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Helman, Elena, Lander, Eric Steven
Бусад зохиолчид:	Harvard University--MIT Division of Health Sciences and Technology
Формат:	Өгүүллэг
Хэл сонгох:	en_US
Хэвлэсэн:	Nature Publishing Group 2015
Онлайн хандалт:	http://hdl.handle.net/1721.1/96673

Ижил төстэй зүйлс

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
-н: Cibulskis, Kristian, зэрэг
Хэвлэсэн: (2014)

Somatic retrotransposition in the cancer genome
-н: Helman, Elena
Хэвлэсэн: (2014)

Punctuated Evolution of Prostate Cancer Genomes
-н: Lander, Eric Steven
Хэвлэсэн: (2016)

Mutations driving CLL and their evolution in progression and relapse
-н: Lander, Eric Steven
Хэвлэсэн: (2017)

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
-н: Sandy, Peter, зэрэг
Хэвлэсэн: (2015)

The Cancer Genome Atlas Pan-Cancer analysis project
-н: Park, Peter J., зэрэг
Хэвлэсэн: (2014)

A polygenic burden of rare disruptive mutations in schizophrenia
-н: Lander, Eric Steven
Хэвлэсэн: (2015)

Comprehensive molecular characterization of human colon and rectal cancer
-н: Lander, Eric Steven
Хэвлэсэн: (2014)

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
-н: Lander, Eric Steven
Хэвлэсэн: (2013)

The landscape of somatic copy-number alteration across human cancers
-н: Lander, Eric Steven
Хэвлэсэн: (2012)

Comprehensive assessment of cancer missense mutation clustering in protein structures
-н: Kamburov, Atanas, зэрэг
Хэвлэсэн: (2018)

Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
-н: Lander, Eric Steven
Хэвлэсэн: (2015)

Whole-exome sequencing and clinical interpretation of FFPE tumor samples to guide precision cancer medicine
-н: Lander, Eric Steven
Хэвлэсэн: (2015)

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
-н: Lander, Eric Steven
Хэвлэсэн: (2014)

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
-н: Lander, Eric Steven
Хэвлэсэн: (2012)

Comprehensive genomic characterization of squamous cell lung cancers
-н: Park, Peter J., зэрэг
Хэвлэсэн: (2014)

Mutation characteristics of cancer susceptibility genes in Chinese ovarian cancer patients
-н: Jie Wang, зэрэг
Хэвлэсэн: (2024-05-01)

Brave New Genome
-н: Lander, Eric Steven
Хэвлэсэн: (2017)

Mutations in the AXIN1 gene in advanced prostate cancer.
-н: Yardy, G, зэрэг
Хэвлэсэн: (2009)

radioGWAS links radiome to genome to discover driver genes with somatic mutations for heterogeneous tumor image phenotype in pancreatic cancer
-н: Dandan Zheng, зэрэг
Хэвлэсэн: (2024-05-01)

Predictive modeling of gene mutations for the survival outcomes of epithelial ovarian cancer patients
-н: Mirielle C. Ma, зэрэг
Хэвлэсэн: (2024-01-01)

Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene?
-н: Lipton, L, зэрэг
Хэвлэсэн: (2001)

CRISPR-mediated direct mutation of cancer genes in the mouse liver
-н: Xue, Wen, зэрэг
Хэвлэсэн: (2015)

RNF43 is frequently mutated in colorectal and endometrial cancers
-н: Giannakis, Marios, зэрэг
Хэвлэсэн: (2018)

Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios
-н: Dong-Jin Han, зэрэг
Хэвлэсэн: (2024-08-01)

Germline mutations in cancer predisposition genes are frequent in sporadic sarcomas
-н: Chan, Sock Hoai, зэрэг
Хэвлэсэн: (2018)

Breast cancer and ATM mutations: treatment implications
-н: Marta Seca, зэрэг
Хэвлэсэн: (2024-11-01)

Somatic mutational landscape reveals mutational signatures and significantly mutated genes of cancer immunotherapeutic outcome and sex disparities
-н: Yuting Li, зэрэг
Хэвлэсэн: (2024-11-01)

KRAS, p53 and BRAF Gene Mutations and Aneuploidy in Sporadic Colorectal Cancer Progression
-н: Daniele Calistri, зэрэг
Хэвлэсэн: (2006-01-01)

Recurrent and functional regulatory mutations in breast cancer
-н: Parasuraman, Prasanna, зэрэг
Хэвлэсэн: (2018)

New mutation of the TP53 gene associated with the hereditary breast cancer in a young Tuvinian woman
-н: P. A. Gervas, зэрэг
Хэвлэсэн: (2022-01-01)

Discovery and saturation analysis of cancer genes across 21 tumour types
-н: Lawrence, Michael S., зэрэг
Хэвлэсэн: (2015)

The genomic complexity of primary human prostate cancer
-н: Carter, Scott L., зэрэг
Хэвлэсэн: (2012)

Colorectal cancer prognosis: is it all mutation, mutation, mutation?
-н: Hassan, A, зэрэг
Хэвлэсэн: (2005)

Mutation analysis of the BRCA1 gene in Malaysian breast cancer patients
-н: Balraj, P., зэрэг
Хэвлэсэн: (2002)

The relationship of P53 gene mutation with clinicopathological characteristic in breast cancer
-н: Amrank, Fitreena Anis
Хэвлэсэн: (2016)

Monitoring changes in the P53 gene mutation to diagnose oral cancer
-н: Thangavel Lakshmipriya, зэрэг
Хэвлэсэн: (2024-06-01)

Inferring the temporal order of cancer gene mutations in individual tumor samples.
-н: Jun Guo, зэрэг
Хэвлэсэн: (2014-01-01)

ANALYSIS OF MUTATIONS IN KRAS AND BRAF GENES IN COLORECTAL CANCER IN RUSSIAN PATIENTS
-н: E. E. Pisareva, зэрэг
Хэвлэсэн: (2016-07-01)

Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer
-н: Tarun Karthik Kumar Mamidi, зэрэг
Хэвлэсэн: (2019-01-01)