Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae

The target of rapamycin (TOR) is a critical regulator of growth, survival, and energy metabolism. The allosteric TORC1 inhibitor rapamycin has been used extensively to elucidate the TOR related signal pathway but is limited by its inability to inhibit TORC2. We used an unbiased cell proliferation as...

Full description

Bibliographic Details
Main Authors:	Liu, Qingsong, Ren, Tao, Fresques, Tara, Oppliger, Wolfgang, Niles, Brad J., Hur, Wooyoung, Hall, Michael N., Powers, Ted, Gray, Nathanael S., Sabatini, David
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	American Chemical Society (ACS) 2015
Online Access:	http://hdl.handle.net/1721.1/96732 https://orcid.org/0000-0002-1446-7256

Similar Items

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae
by: Joseph I. Kliegman, et al.
Published: (2013-12-01)

Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly
by: Andrew Hill, et al.
Published: (2018-06-01)

TOR Complex 2-Ypk1 Signaling Maintains Sphingolipid Homeostasis by Sensing and Regulating ROS Accumulation
by: Brad J. Niles, et al.
Published: (2014-02-01)

TOR Complex 2-Ypk1 Signaling Maintains Sphingolipid Homeostasis by Sensing and Regulating ROS Accumulation
by: Brad J. Niles, et al.
Published: (2014-02-01)

Rapamycin inhibits mTORC1, but not completely
by: Thoreen, Carson C, et al.
Published: (2012)

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
by: Cervantes, Christopher L., et al.
Published: (2014)

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
by: Kang, Seong A., et al.
Published: (2014)

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
by: Morris E Feldman, et al.
Published: (2009-02-01)

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer
by: Liu, Qingsong, et al.
Published: (2014)

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
by: Liu, Qingsong, et al.
Published: (2015)

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer
by: Liu, Qingsong, et al.
Published: (2012)

On the Discovery of TOR As the Target of Rapamycin.
by: Joseph Heitman
Published: (2015-01-01)

<it>Saccharomyces cerevisiae </it>FKBP12 binds <it>Arabidopsis thaliana </it>TOR and its expression in plants leads to rapamycin susceptibility
by: Meyer Christian, et al.
Published: (2007-06-01)

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
by: Ye, Lan, et al.
Published: (2018)

Structure of the human mTOR Complex I and its implications for rapamycin inhibition
by: Yip, Calvin K., et al.
Published: (2012)

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
by: Lan eYe, et al.
Published: (2012-09-01)

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
by: Lamming, Dudley W., et al.
Published: (2014)

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
by: Rameseder, J., et al.
Published: (2013)

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
by: James T. Murray, et al.
Published: (2018-05-01)

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
by: Robida-Stubbs, Stacey, et al.
Published: (2014)

Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.
by: Chenggang Li, et al.
Published: (2014-01-01)

A unifying model for mTORC1-mediated regulation of mRNA translation
by: Thoreen, Carson C., et al.
Published: (2014)

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases
by: Michael Wong
Published: (2014-04-01)

Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2.
by: Weijie Wang, et al.
Published: (2014-01-01)

The TORC2‐Dependent Signaling Network in the Yeast Saccharomyces cerevisiae
by: Françoise M. Roelants, et al.
Published: (2017-09-01)

17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling.
by: Angelika Kusch, et al.
Published: (2015-01-01)

TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia.
by: Pablo Calap-Quintana, et al.
Published: (2015-01-01)

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe
by: Nobuyasu Ikai, et al.
Published: (2011-01-01)

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
by: Manikandan Karuppasamy, et al.
Published: (2017-11-01)

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy
by: Wei Zhao, et al.
Published: (2023-06-01)

FERONIA functions through Target of Rapamycin (TOR) to negatively regulate autophagy
by: Ping Wang, et al.
Published: (2022-08-01)

Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
by: Belinda Seto
Published: (2012-12-01)

Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1).
by: Gokhan Demirkan, et al.
Published: (2011-01-01)

Tomato FK506 Binding Protein 12KD (FKBP12) mediates the interaction between rapamycin and Target of Rapamycin (TOR)
by: Fangjie Xiong, et al.
Published: (2016-11-01)

Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae.
by: Joanne M Kingsbury, et al.
Published: (2015-12-01)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding [v1; ref status: indexed, http://f1000r.es/NM6hpo]
by: Mark Livingstone, et al.
Published: (2012-07-01)

Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis.
by: Brian Dimitroff, et al.
Published: (2012-01-01)

Target of Rapamycin (TOR) Negatively Regulates Ethylene Signals in <i>Arabidopsis</i>
by: Fengping Zhuo, et al.
Published: (2020-04-01)

The Plant Target of Rapamycin: A Conduc TOR of Nutrition and Metabolism in Photosynthetic Organisms
by: Camille Ingargiola, et al.
Published: (2020-10-01)

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.
by: Xiaoli Zhang, et al.
Published: (2019-05-01)