A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to environmental cues. However, the mechanisms mediating lysosomal adaptation are largely unknown. Here, we show that the Transcription Factor EB (TFEB), a master regulator o...

Full description

Bibliographic Details
Main Authors: Settembre, Carmine, Zoncu, Roberto, Medina, Diego L., Vetrini, Francesco, Erdin, Serkan, Erdin, SerpilUckac, Huynh, Tuong, Ferron, Mathieu, Karsenty, Gerard, Vellard, Michel C., Facchinetti, Valeria, Ballabio, Andrea, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: EMBRO Press 2015
Online Access:http://hdl.handle.net/1721.1/96733
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/96733
https://orcid.org/0000-0002-1446-7256

Similar Items