Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Ragulator-, and vacuolar adenosine triphosphatase–dependent fashion, the translocation of mTORC1 to the lysosomal surface...

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Bibliographic Details
Main Authors: Plovanich, M. E., Straub, C., Sabatini, B. L., Tsun, Zhi-Yang, Wang, Shuyu, Wolfson, Rachel Laura, Shen, Kuang, Wyant, Gregory Andrew, Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William C., Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Kim, Choah, Park, Jiwon, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2015
Online Access:http://hdl.handle.net/1721.1/96751
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0001-6366-7986
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0001-9388-1633

Internet

http://hdl.handle.net/1721.1/96751
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0001-6366-7986
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0001-9388-1633

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