Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism
Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society (ACS)
2015
|
| Online Access: | http://hdl.handle.net/1721.1/96754 https://orcid.org/0000-0002-2325-552X https://orcid.org/0000-0001-9307-6116 |
| _version_ | 1826204829713694720 |
|---|---|
| author | Lu, Kun Mahbub, Ridwan Cable, Peter Hans Ru, Hongyu Parry, Nicola M. A. Bodnar, Wanda M. Wishnok, John S. Styblo, Miroslav Swenberg, James A. Fox, James G. Tannenbaum, Steven Robert |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Lu, Kun Mahbub, Ridwan Cable, Peter Hans Ru, Hongyu Parry, Nicola M. A. Bodnar, Wanda M. Wishnok, John S. Styblo, Miroslav Swenberg, James A. Fox, James G. Tannenbaum, Steven Robert |
| author_sort | Lu, Kun |
| collection | MIT |
| description | Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism. |
| first_indexed | 2024-09-23T13:02:03Z |
| format | Article |
| id | mit-1721.1/96754 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:02:03Z |
| publishDate | 2015 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/967542022-10-01T12:38:01Z Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism Lu, Kun Mahbub, Ridwan Cable, Peter Hans Ru, Hongyu Parry, Nicola M. A. Bodnar, Wanda M. Wishnok, John S. Styblo, Miroslav Swenberg, James A. Fox, James G. Tannenbaum, Steven Robert Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Division of Comparative Medicine Lu, Kun Parry, Nicola M. A. Wishnok, John S. Fox, James G. Tannenbaum, Steven Robert Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism. National Institute of Environmental Health Sciences (P30 ES010126) National Institute of Environmental Health Sciences (NIEHS grant P30 ES002109) University of Georgia. College of Public Health (internal grant) University of Georgia (Faculty Research Grant (FRG)) 2015-04-23T18:26:57Z 2015-04-23T18:26:57Z 2014-02 2013-12 Article http://purl.org/eprint/type/JournalArticle 0893-228X 1520-5010 http://hdl.handle.net/1721.1/96754 Lu, Kun, Ridwan Mahbub, Peter Hans Cable, Hongyu Ru, Nicola M. A. Parry, Wanda M. Bodnar, John S. Wishnok, et al. “Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism.” Chemical Research in Toxicology 27, no. 2 (February 17, 2014): 172–174. © 2014 American Chemical Society. https://orcid.org/0000-0002-2325-552X https://orcid.org/0000-0001-9307-6116 en_US http://dx.doi.org/10.1021/tx400454z Chemical Research in Toxicology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) American Chemical Society |
| spellingShingle | Lu, Kun Mahbub, Ridwan Cable, Peter Hans Ru, Hongyu Parry, Nicola M. A. Bodnar, Wanda M. Wishnok, John S. Styblo, Miroslav Swenberg, James A. Fox, James G. Tannenbaum, Steven Robert Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism |
| title | Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism |
| title_full | Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism |
| title_fullStr | Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism |
| title_full_unstemmed | Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism |
| title_short | Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism |
| title_sort | gut microbiome phenotypes driven by host genetics affect arsenic metabolism |
| url | http://hdl.handle.net/1721.1/96754 https://orcid.org/0000-0002-2325-552X https://orcid.org/0000-0001-9307-6116 |
| work_keys_str_mv | AT lukun gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT mahbubridwan gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT cablepeterhans gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT ruhongyu gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT parrynicolama gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT bodnarwandam gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT wishnokjohns gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT styblomiroslav gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT swenbergjamesa gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT foxjamesg gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism AT tannenbaumstevenrobert gutmicrobiomephenotypesdrivenbyhostgeneticsaffectarsenicmetabolism |