miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain
microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These micro...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/96766 |
| _version_ | 1826215277029752832 |
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| author | Cannella, Dominique Brenier-Pinchart, Marie-Pierre Braun, Laurence van Rooyen, Jason M. Bougdour, Alexandre Bastien, Olivier Behnke, Michael S. Curt, Rose-Laurence Sibley, L. David Hakimi, Mohamed-Ali Saeij, Jeroen Curt, Aurelie Pelloux, Herve |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Cannella, Dominique Brenier-Pinchart, Marie-Pierre Braun, Laurence van Rooyen, Jason M. Bougdour, Alexandre Bastien, Olivier Behnke, Michael S. Curt, Rose-Laurence Sibley, L. David Hakimi, Mohamed-Ali Saeij, Jeroen Curt, Aurelie Pelloux, Herve |
| author_sort | Cannella, Dominique |
| collection | MIT |
| description | microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice. |
| first_indexed | 2024-09-23T16:21:28Z |
| format | Article |
| id | mit-1721.1/96766 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:21:28Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/967662022-09-29T19:39:23Z miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain Cannella, Dominique Brenier-Pinchart, Marie-Pierre Braun, Laurence van Rooyen, Jason M. Bougdour, Alexandre Bastien, Olivier Behnke, Michael S. Curt, Rose-Laurence Sibley, L. David Hakimi, Mohamed-Ali Saeij, Jeroen Curt, Aurelie Pelloux, Herve Massachusetts Institute of Technology. Department of Biology Saeij, Jeroen microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice. France. Agence nationale de la recherche (Blanc 2010 Grant APImiR ANR 2010 BLAN 1315 01) France. Agence nationale de la recherche (Blanc ToxoHDAC ANR-12-BSV3-0009-01) France. Agence nationale de la recherche (LabEx ParaFrap ANR-11-LABX-0024) 2015-04-23T19:52:56Z 2015-04-23T19:52:56Z 2014-02 2014-01 Article http://purl.org/eprint/type/JournalArticle 22111247 http://hdl.handle.net/1721.1/96766 Cannella, Dominique, Marie-Pierre Brenier-Pinchart, Laurence Braun, Jason M. van Rooyen, Alexandre Bougdour, Olivier Bastien, Michael S. Behnke, et al. “miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain.” Cell Reports 6, no. 5 (March 2014): 928–937. en_US http://dx.doi.org/10.1016/j.celrep.2014.02.002 Cell Reports Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License http://creativecommons.org/licenses/by-nc-nd/3.0/ application/pdf Elsevier Elsevier Open Access |
| spellingShingle | Cannella, Dominique Brenier-Pinchart, Marie-Pierre Braun, Laurence van Rooyen, Jason M. Bougdour, Alexandre Bastien, Olivier Behnke, Michael S. Curt, Rose-Laurence Sibley, L. David Hakimi, Mohamed-Ali Saeij, Jeroen Curt, Aurelie Pelloux, Herve miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain |
| title | miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain |
| title_full | miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain |
| title_fullStr | miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain |
| title_full_unstemmed | miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain |
| title_short | miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain |
| title_sort | mir 146a and mir 155 delineate a microrna fingerprint associated with toxoplasma persistence in the host brain |
| url | http://hdl.handle.net/1721.1/96766 |
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