A Circuitous Route to Noncoding RNA
Most genetic information is expressed as, and transacted by, proteins. Yet, less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% of the genome, once considered to be mostly “junk DNA.” Transcription is pervasive, however, and high-throughpu...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Association for the Advancement of Science (AAAS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/96798 https://orcid.org/0000-0003-1465-1691 |
| _version_ | 1826210732194136064 |
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| author | Sharp, Phillip A. Wilusz, Jeremy |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sharp, Phillip A. Wilusz, Jeremy |
| author_sort | Sharp, Phillip A. |
| collection | MIT |
| description | Most genetic information is expressed as, and transacted by, proteins. Yet, less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% of the genome, once considered to be mostly “junk DNA.” Transcription is pervasive, however, and high-throughput sequencing has identified tens of thousands of distinct RNAs generated from the non—protein—coding portion of the genome (1). These so-called noncoding RNAs vary in length, but like protein-coding RNAs, appear to be linear molecules with 5′ and 3′ termini, reflecting the defined start and end points of RNA polymerase on the DNA template. But do all RNAs have to be linear? |
| first_indexed | 2024-09-23T14:54:50Z |
| format | Article |
| id | mit-1721.1/96798 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:54:50Z |
| publishDate | 2015 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/967982022-09-29T11:22:20Z A Circuitous Route to Noncoding RNA Sharp, Phillip A. Wilusz, Jeremy Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Wilusz, Jeremy E. Sharp, Phillip A. Most genetic information is expressed as, and transacted by, proteins. Yet, less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% of the genome, once considered to be mostly “junk DNA.” Transcription is pervasive, however, and high-throughput sequencing has identified tens of thousands of distinct RNAs generated from the non—protein—coding portion of the genome (1). These so-called noncoding RNAs vary in length, but like protein-coding RNAs, appear to be linear molecules with 5′ and 3′ termini, reflecting the defined start and end points of RNA polymerase on the DNA template. But do all RNAs have to be linear? 2015-04-24T18:25:56Z 2015-04-24T18:25:56Z 2013-04 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/96798 Wilusz, J. E., and P. A. Sharp. “A Circuitous Route to Noncoding RNA.” Science 340, no. 6131 (April 25, 2013): 440–441. https://orcid.org/0000-0003-1465-1691 en_US http://dx.doi.org/10.1126/science.1238522 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Sharp, Phillip A. Wilusz, Jeremy A Circuitous Route to Noncoding RNA |
| title | A Circuitous Route to Noncoding RNA |
| title_full | A Circuitous Route to Noncoding RNA |
| title_fullStr | A Circuitous Route to Noncoding RNA |
| title_full_unstemmed | A Circuitous Route to Noncoding RNA |
| title_short | A Circuitous Route to Noncoding RNA |
| title_sort | circuitous route to noncoding rna |
| url | http://hdl.handle.net/1721.1/96798 https://orcid.org/0000-0003-1465-1691 |
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