mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

mTOR complex 2 (mTORC2) contains the mammalian target of rapamycin (mTOR) kinase and the Rictor regulatory protein and phosphorylates Akt. Whether this function of mTORC2 is critical for cancer progression is unknown. Here, we show that transformed human prostate epithelial cells lacking PTEN requir...

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Bibliographic Details
Main Authors: Guertin, David A., Stevens, Deanna M., Saitoh, Maki, Kinkel, Stephanie, Crosby, Katherine, Sheen, Joon-Ho, Mullholland, David J., Magnuson, Mark A., Wu, Hong, Sabatini, David
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:en_US
Published: Elsevier B.V. 2015
Online Access:http://hdl.handle.net/1721.1/96802
https://orcid.org/0000-0002-1446-7256

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