Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans
Analyses of gene expression profiles in evolutionarily diverse organisms have revealed a role for microRNAs in tuning tissue-specific gene expression. Here, we show that the relatively abundant and constitutively expressed miR-58 family of microRNAs sharply defines the tissue-specific expression of...
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2015
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| Online Access: | http://hdl.handle.net/1721.1/96836 https://orcid.org/0000-0002-4109-5152 https://orcid.org/0000-0003-4295-4518 |
| _version_ | 1826202763062673408 |
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| author | Kim, Dennis H. Kingston, Elena Pagano, Daniel Joseph |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kim, Dennis H. Kingston, Elena Pagano, Daniel Joseph |
| author_sort | Kim, Dennis H. |
| collection | MIT |
| description | Analyses of gene expression profiles in evolutionarily diverse organisms have revealed a role for microRNAs in tuning tissue-specific gene expression. Here, we show that the relatively abundant and constitutively expressed miR-58 family of microRNAs sharply defines the tissue-specific expression of the broadly transcribed gene encoding PMK-2 p38 MAPK in Caenorhabditis elegans. Whereas PMK-2 functions redundantly with PMK-1 in the nervous system to regulate neuronal development and behavioral responses to pathogenic bacteria, the miR-58, miR-80, miR-81, and miR-82 microRNAs function redundantly to destabilize pmk-2 mRNA in non-neuronal cells with switch-like potency. Our data suggest a role for the miR-58 family in the establishment of neuronal-specific gene expression in C. elegans, and support a more general role for microRNAs in the establishment of tissue-specific gene expression. |
| first_indexed | 2024-09-23T12:16:55Z |
| format | Article |
| id | mit-1721.1/96836 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:16:55Z |
| publishDate | 2015 |
| publisher | Public Library of Science |
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| spelling | mit-1721.1/968362022-10-01T08:52:48Z Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans Kim, Dennis H. Kingston, Elena Pagano, Daniel Joseph Massachusetts Institute of Technology. Department of Biology Pagano, Daniel J. Kingston, Elena Kim, Dennis H. Analyses of gene expression profiles in evolutionarily diverse organisms have revealed a role for microRNAs in tuning tissue-specific gene expression. Here, we show that the relatively abundant and constitutively expressed miR-58 family of microRNAs sharply defines the tissue-specific expression of the broadly transcribed gene encoding PMK-2 p38 MAPK in Caenorhabditis elegans. Whereas PMK-2 functions redundantly with PMK-1 in the nervous system to regulate neuronal development and behavioral responses to pathogenic bacteria, the miR-58, miR-80, miR-81, and miR-82 microRNAs function redundantly to destabilize pmk-2 mRNA in non-neuronal cells with switch-like potency. Our data suggest a role for the miR-58 family in the establishment of neuronal-specific gene expression in C. elegans, and support a more general role for microRNAs in the establishment of tissue-specific gene expression. National Institutes of Health (U.S.) (Grant R01-GM084477) 2015-04-28T20:39:44Z 2015-04-28T20:39:44Z 2015-02 2014-12 Article http://purl.org/eprint/type/JournalArticle 1553-7404 1553-7390 http://hdl.handle.net/1721.1/96836 Pagano, Daniel J., Elena R. Kingston, and Dennis H. Kim. “Tissue Expression Pattern of PMK-2 P38 MAPK Is Established by the miR-58 Family in C. Elegans.” PLoS Genet 11, no. 2 (February 11, 2015): e1004997. https://orcid.org/0000-0002-4109-5152 https://orcid.org/0000-0003-4295-4518 en_US http://dx.doi.org/10.1371/journal.pgen.1004997 PLOS Genetics Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science Public Library of Science |
| spellingShingle | Kim, Dennis H. Kingston, Elena Pagano, Daniel Joseph Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans |
| title | Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans |
| title_full | Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans |
| title_fullStr | Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans |
| title_full_unstemmed | Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans |
| title_short | Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans |
| title_sort | tissue expression pattern of pmk 2 p38 mapk is established by the mir 58 family in c elegans |
| url | http://hdl.handle.net/1721.1/96836 https://orcid.org/0000-0002-4109-5152 https://orcid.org/0000-0003-4295-4518 |
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