A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Cancer cells possess aberrant proteomes that can arise by the disruption of genes involved in physiological protein degradation. Here we demonstrate the presence of promoter CpG island hypermethylation-linked inactivation of DERL3 (Derlin-3), a key gene in the endoplasmic reticulum-associated protei...

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Bibliographic Details
Main Authors: Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., Bramsem, Jesper B., Andersen, Claus L., Tabernero, Josep, McDermott, Ultan, Boxer, Matthew B., Albar, Juan Pablo, Esteller, Manel, Vander Heiden, Matthew G., Leal, Lucia, Orntoft, Torben F.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96845
https://orcid.org/0000-0002-6702-4192

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