Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein
Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay wit...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry
2015
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| Online Access: | http://hdl.handle.net/1721.1/96893 https://orcid.org/0000-0003-1720-0183 https://orcid.org/0000-0002-7096-138X |
| Summary: | Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis. |
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