Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures
A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are highly deformed together with the...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Wiley Blackwell
2015
|
| Online Access: | http://hdl.handle.net/1721.1/97186 https://orcid.org/0000-0001-5387-6186 |
| _version_ | 1826202884725800960 |
|---|---|
| author | Hong, Sungmin Sycks, Dalton Chan, Hon Fai Lin, Shaoting Lopez, Gabriel P. Guilak, Farshid Leong, Kam W. Zhao, Xuanhe |
| author2 | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Hong, Sungmin Sycks, Dalton Chan, Hon Fai Lin, Shaoting Lopez, Gabriel P. Guilak, Farshid Leong, Kam W. Zhao, Xuanhe |
| author_sort | Hong, Sungmin |
| collection | MIT |
| description | A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are highly deformed together with the hydrogel. By adding biocompatible nanoclay, the tough hydrogel is 3D printed in various shapes without requiring support material. |
| first_indexed | 2024-09-23T12:24:19Z |
| format | Article |
| id | mit-1721.1/97186 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:24:19Z |
| publishDate | 2015 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/971862022-10-01T09:04:53Z Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures Hong, Sungmin Sycks, Dalton Chan, Hon Fai Lin, Shaoting Lopez, Gabriel P. Guilak, Farshid Leong, Kam W. Zhao, Xuanhe Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Zhao, Xuanhe Lin, Shaoting Zhao, Xuanhe A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are highly deformed together with the hydrogel. By adding biocompatible nanoclay, the tough hydrogel is 3D printed in various shapes without requiring support material. National Institutes of Health (U.S.) (Grant UH3TR000505) National Institutes of Health (U.S.) (Grant R01AR48825) National Institutes of Health (U.S.) (Common Fund for the Microphysiological Systems Initiative) AOSpine Foundation National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (DRM-1121107) 2015-06-05T14:03:17Z 2015-06-05T14:03:17Z 2015-05 2015-04 Article http://purl.org/eprint/type/JournalArticle 09359648 1521-4095 http://hdl.handle.net/1721.1/97186 Hong, Sungmin et al. “3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures.” Advanced Materials (2015): n/a–n/a. https://orcid.org/0000-0001-5387-6186 en_US http://dx.doi.org/10.1002/adma.201501099 Advanced Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell Zhao |
| spellingShingle | Hong, Sungmin Sycks, Dalton Chan, Hon Fai Lin, Shaoting Lopez, Gabriel P. Guilak, Farshid Leong, Kam W. Zhao, Xuanhe Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures |
| title | Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures |
| title_full | Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures |
| title_fullStr | Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures |
| title_full_unstemmed | Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures |
| title_short | Three-Dimensional Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures |
| title_sort | three dimensional printing of highly stretchable and tough hydrogels into complex cellularized structures |
| url | http://hdl.handle.net/1721.1/97186 https://orcid.org/0000-0001-5387-6186 |
| work_keys_str_mv | AT hongsungmin threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT sycksdalton threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT chanhonfai threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT linshaoting threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT lopezgabrielp threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT guilakfarshid threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT leongkamw threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT zhaoxuanhe threedimensionalprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT hongsungmin 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT sycksdalton 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT chanhonfai 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT linshaoting 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT lopezgabrielp 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT guilakfarshid 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT leongkamw 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures AT zhaoxuanhe 3dprintingofhighlystretchableandtoughhydrogelsintocomplexcellularizedstructures |