A method for human teratogen detection by geometrically confined cell differentiation and migration

Unintended exposure to teratogenic compounds can lead to various birth defects; however current animal-based testing is limited by time, cost and high inter-species variability. Here, we developed a human-relevant in vitro model, which recapitulated two cellular events characteristic of embryogenesi...

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Bibliographic Details
Main Authors: Xing, Jiangwa, Toh, Yi-Chin, Xu, Shuoyu, Yu, Hanry
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/97223
https://orcid.org/0000-0002-0339-3685