Molecular Analysis of TTP, a Key Regulator of TNFα Activity
The immediate-early protein tristetraprolin (TTP) is induced by numerous extracellular stimuli and during some apoptotic events. TTP and the related proteins TIS11b and TIS11d (TTP/TIS11 proteins) are members of a family with highly conserved Cys3His zinc fingers that are associated with RNA binding...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/1721.1/97235 https://orcid.org/0000-0002-9547-3251 |
| _version_ | 1826217518699642880 |
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| author | Johnson, Barbra A. Blackwell, T. Keith Yaffe, Michael B |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Johnson, Barbra A. Blackwell, T. Keith Yaffe, Michael B |
| author_sort | Johnson, Barbra A. |
| collection | MIT |
| description | The immediate-early protein tristetraprolin (TTP) is induced by numerous extracellular stimuli and during some apoptotic events. TTP and the related proteins TIS11b and TIS11d (TTP/TIS11 proteins) are members of a family with highly conserved Cys3His zinc fingers that are associated with RNA binding. In mice, lack of TTP causes an inflammatory syndrome that is mediated by TNFα 1, and evidence indicates that TTP can bind and destabilize TNFα and other cytokine mRNAs2. In vitro, all three TTP/TIS11 proteins possess this activity and it is present within the zinc finger region3. Several precedents suggest however that TTP/TIS11 proteins may also be implicated in survival, growth, or apoptotic pathways; a model we have addressed in this study. |
| first_indexed | 2024-09-23T17:04:57Z |
| format | Article |
| id | mit-1721.1/97235 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:04:57Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/972352022-10-03T10:14:42Z Molecular Analysis of TTP, a Key Regulator of TNFα Activity Johnson, Barbra A. Blackwell, T. Keith Yaffe, Michael B Massachusetts Institute of Technology. Department of Biology Yaffe, Michael B. The immediate-early protein tristetraprolin (TTP) is induced by numerous extracellular stimuli and during some apoptotic events. TTP and the related proteins TIS11b and TIS11d (TTP/TIS11 proteins) are members of a family with highly conserved Cys3His zinc fingers that are associated with RNA binding. In mice, lack of TTP causes an inflammatory syndrome that is mediated by TNFα 1, and evidence indicates that TTP can bind and destabilize TNFα and other cytokine mRNAs2. In vitro, all three TTP/TIS11 proteins possess this activity and it is present within the zinc finger region3. Several precedents suggest however that TTP/TIS11 proteins may also be implicated in survival, growth, or apoptotic pathways; a model we have addressed in this study. Breast Cancer Research Program (U.S.) (17-94-J-4063) National Institutes of Health (U.S.) (Grant PO1 HD17461) Arthritis Foundation (Postdoctoral Fellowship) 2015-06-09T13:48:28Z 2015-06-09T13:48:28Z 2001 2015-06-06T07:01:08Z Article http://purl.org/eprint/type/JournalArticle 1537-744X http://hdl.handle.net/1721.1/97235 Johnson, Barbra A., Michael Yaffe, and T. Keith Blackwell. “Molecular Analysis of TTP, a Key Regulator of TNFα Activity.” The Scientific World JOURNAL 1 (2001): 38–38. https://orcid.org/0000-0002-9547-3251 en http://dx.doi.org/10.1100/tsw.2001.140 The Scientific World JOURNAL Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2001 Barbra A. Johnson et al. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Johnson, Barbra A. Blackwell, T. Keith Yaffe, Michael B Molecular Analysis of TTP, a Key Regulator of TNFα Activity |
| title | Molecular Analysis of TTP, a Key Regulator of TNFα Activity |
| title_full | Molecular Analysis of TTP, a Key Regulator of TNFα Activity |
| title_fullStr | Molecular Analysis of TTP, a Key Regulator of TNFα Activity |
| title_full_unstemmed | Molecular Analysis of TTP, a Key Regulator of TNFα Activity |
| title_short | Molecular Analysis of TTP, a Key Regulator of TNFα Activity |
| title_sort | molecular analysis of ttp a key regulator of tnfα activity |
| url | http://hdl.handle.net/1721.1/97235 https://orcid.org/0000-0002-9547-3251 |
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