Quantitative Solution Measurement for the Selection of Complexing Agents to Enable Purification by Impurity Complexation

Quantitative Solution Measurement for the Selection of Complexing Agents to Enable Purification by Impurity Complexation

The removal of carboxylic acid impurities from amide targets has been accomplished through crystallization featuring a complexing agent in solution. The interaction between the complexing agents and impurities was examined using isothermal titration calorimetry and the free energy of association obt...

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Bibliographic Details
Main Authors:	Weber, Cameron C., Wood, Geoffrey P. F., Kunov-Kruse, Andreas J., Nmagu, Douglas E., Trout, Bernhardt L., Myerson, Allan S.
Other Authors:	Novartis-MIT Center for Continuous Manufacturing
Format:	Article
Language:	en_US
Published:	American Chemical Society (ACS) 2015
Online Access:	http://hdl.handle.net/1721.1/97382 https://orcid.org/0000-0003-1417-9470

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