Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion
Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategie...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2015
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| Online Access: | http://hdl.handle.net/1721.1/97480 https://orcid.org/0000-0002-7232-304X |
| _version_ | 1826209888342114304 |
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| author | Shin, Yoojin Kim, Hyunju Han, Sewoon Won, Jihee Jeong, Hyo Eun Lee, Eun-Sook Kim, Jae-Hong Chung, Seok Kamm, Roger Dale |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Shin, Yoojin Kim, Hyunju Han, Sewoon Won, Jihee Jeong, Hyo Eun Lee, Eun-Sook Kim, Jae-Hong Chung, Seok Kamm, Roger Dale |
| author_sort | Shin, Yoojin |
| collection | MIT |
| description | Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs. |
| first_indexed | 2024-09-23T14:34:05Z |
| format | Article |
| id | mit-1721.1/97480 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:34:05Z |
| publishDate | 2015 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/974802022-10-01T21:42:29Z Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion Shin, Yoojin Kim, Hyunju Han, Sewoon Won, Jihee Jeong, Hyo Eun Lee, Eun-Sook Kim, Jae-Hong Chung, Seok Kamm, Roger Dale Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Kamm, Roger Dale Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs. International Research & Development Program (Grant 2009-00631) National Research Foundation of Korea (Basic Science Research Program Grant 2012-022481) 2015-06-19T18:52:54Z 2015-06-19T18:52:54Z 2012-11 2012-09 Article http://purl.org/eprint/type/JournalArticle 21922640 http://hdl.handle.net/1721.1/97480 Shin, Yoojin, Hyunju Kim, Sewoon Han, Jihee Won, Hyo Eun Jeong, Eun-Sook Lee, Roger D. Kamm, Jae-Hong Kim, and Seok Chung. “Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion.” Advanced Healthcare Materials 2, no. 6 (November 26, 2012): 790–794. https://orcid.org/0000-0002-7232-304X en_US http://dx.doi.org/10.1002/adhm.201200320 Advanced Healthcare Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Shin, Yoojin Kim, Hyunju Han, Sewoon Won, Jihee Jeong, Hyo Eun Lee, Eun-Sook Kim, Jae-Hong Chung, Seok Kamm, Roger Dale Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion |
| title | Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion |
| title_full | Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion |
| title_fullStr | Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion |
| title_full_unstemmed | Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion |
| title_short | Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion |
| title_sort | extracellular matrix heterogeneity regulates three dimensional morphologies of breast adenocarcinoma cell invasion |
| url | http://hdl.handle.net/1721.1/97480 https://orcid.org/0000-0002-7232-304X |
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