Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids
Natural products chemistry has historically been the prime arena for the discovery of new chemical transformations and the fountain of insights into key biological processes. It remains a fervent incubator of progress in the fields of chemistry and biology and an exchange mediating the flow of ideas...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society (ACS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/97486 https://orcid.org/0000-0003-3080-1063 |
| _version_ | 1826216634552942592 |
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| author | Kim, Justin Movassaghi, Mohammad |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Kim, Justin Movassaghi, Mohammad |
| author_sort | Kim, Justin |
| collection | MIT |
| description | Natural products chemistry has historically been the prime arena for the discovery of new chemical transformations and the fountain of insights into key biological processes. It remains a fervent incubator of progress in the fields of chemistry and biology and an exchange mediating the flow of ideas between these allied fields of science. It is with this ethos that our group has taken an interest in and pursued the synthesis of a complex family of natural products termed the dimeric epipolythiodiketopiperazine (ETP) alkaloids. We present here an Account of the highly complex target molecules to which we pegged our ambitions, our systematic and relentless efforts toward those goals, the chemistry we developed in their pursuit, and the insight we have gained for their translational potential as potent anticancer molecules. |
| first_indexed | 2024-09-23T16:50:16Z |
| format | Article |
| id | mit-1721.1/97486 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:50:16Z |
| publishDate | 2015 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/974862022-10-03T08:38:32Z Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids Kim, Justin Movassaghi, Mohammad Massachusetts Institute of Technology. Department of Chemistry Movassaghi, Mohammad Natural products chemistry has historically been the prime arena for the discovery of new chemical transformations and the fountain of insights into key biological processes. It remains a fervent incubator of progress in the fields of chemistry and biology and an exchange mediating the flow of ideas between these allied fields of science. It is with this ethos that our group has taken an interest in and pursued the synthesis of a complex family of natural products termed the dimeric epipolythiodiketopiperazine (ETP) alkaloids. We present here an Account of the highly complex target molecules to which we pegged our ambitions, our systematic and relentless efforts toward those goals, the chemistry we developed in their pursuit, and the insight we have gained for their translational potential as potent anticancer molecules. National Institute of General Medical Sciences (U.S.) (Grant GM089732) Amgen Inc. 2015-06-22T13:20:24Z 2015-06-22T13:20:24Z 2015-04 2014-12 Article http://purl.org/eprint/type/JournalArticle 0001-4842 1520-4898 http://hdl.handle.net/1721.1/97486 Kim, Justin, and Mohammad Movassaghi. “Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids.” Accounts of Chemical Research 48, no. 4 (April 21, 2015): 1159–1171. © 2015 American Chemical Society https://orcid.org/0000-0003-3080-1063 en_US http://dx.doi.org/10.1021/ar500454v Accounts of Chemical Research Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) American Chemical Society |
| spellingShingle | Kim, Justin Movassaghi, Mohammad Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids |
| title | Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids |
| title_full | Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids |
| title_fullStr | Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids |
| title_full_unstemmed | Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids |
| title_short | Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids |
| title_sort | biogenetically inspired total synthesis of epidithiodiketopiperazines and related alkaloids |
| url | http://hdl.handle.net/1721.1/97486 https://orcid.org/0000-0003-3080-1063 |
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