Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors
Mesenchymal stem/stromal cells (MSCs) represent a promising adult progenitor cell source for tissue repair and regeneration. Their mysterious identity in situ has gradually been unveiled by the accumulating evidence indicating an association between adult multipotent stem/progenitor cells and vascul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/1721.1/98010 https://orcid.org/0000-0002-6891-3557 |
| _version_ | 1826216401627512832 |
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| author | Huard, Johnny Chen, Chien Wen Peault, Bruno |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Huard, Johnny Chen, Chien Wen Peault, Bruno |
| author_sort | Huard, Johnny |
| collection | MIT |
| description | Mesenchymal stem/stromal cells (MSCs) represent a promising adult progenitor cell source for tissue repair and regeneration. Their mysterious identity in situ has gradually been unveiled by the accumulating evidence indicating an association between adult multipotent stem/progenitor cells and vascular/perivascular niches. Using immunohistochemistry and fluorescence-activated cell sorting, we and other groups have prospectively identified and purified subpopulations of multipotent precursor cells associated with the blood vessels within multiple human organs. The three precursor subsets, myogenic endothelial cells (MECs), pericytes (PCs), and adventitial cells (ACs), are located, respectively, in the three structural tiers of typical blood vessels: intima, media, and adventitia. MECs, PCs, and ACs have been extensively characterized in prior studies and are currently under investigation for their therapeutic potentials in preclinical animal models. In this review, we will briefly discuss the identification, isolation, and characterization of these human blood-vessel-derived stem cells (hBVSCs) and summarize the current status of regenerative applications of hBVSC subsets. |
| first_indexed | 2024-09-23T16:47:05Z |
| format | Article |
| id | mit-1721.1/98010 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:47:05Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/980102022-09-29T21:27:16Z Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors Huard, Johnny Chen, Chien Wen Peault, Bruno Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Research Laboratory of Electronics Chen, Chien Wen Mesenchymal stem/stromal cells (MSCs) represent a promising adult progenitor cell source for tissue repair and regeneration. Their mysterious identity in situ has gradually been unveiled by the accumulating evidence indicating an association between adult multipotent stem/progenitor cells and vascular/perivascular niches. Using immunohistochemistry and fluorescence-activated cell sorting, we and other groups have prospectively identified and purified subpopulations of multipotent precursor cells associated with the blood vessels within multiple human organs. The three precursor subsets, myogenic endothelial cells (MECs), pericytes (PCs), and adventitial cells (ACs), are located, respectively, in the three structural tiers of typical blood vessels: intima, media, and adventitia. MECs, PCs, and ACs have been extensively characterized in prior studies and are currently under investigation for their therapeutic potentials in preclinical animal models. In this review, we will briefly discuss the identification, isolation, and characterization of these human blood-vessel-derived stem cells (hBVSCs) and summarize the current status of regenerative applications of hBVSC subsets. 2015-08-04T16:10:57Z 2015-08-04T16:10:57Z 2015 2014-09 2015-08-01T07:00:30Z Article http://purl.org/eprint/type/JournalArticle 1687-966X 1687-9678 http://hdl.handle.net/1721.1/98010 Chen, William C. W., Bruno Peault, and Johnny Huard. “Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors.” Stem Cells International 2015 (2015): 1–11. https://orcid.org/0000-0002-6891-3557 en http://dx.doi.org/10.1155/2015/375187 Stem Cells International Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2015 William C. W. Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Huard, Johnny Chen, Chien Wen Peault, Bruno Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors |
| title | Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors |
| title_full | Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors |
| title_fullStr | Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors |
| title_full_unstemmed | Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors |
| title_short | Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors |
| title_sort | regenerative translation of human blood vessel derived msc precursors |
| url | http://hdl.handle.net/1721.1/98010 https://orcid.org/0000-0002-6891-3557 |
| work_keys_str_mv | AT huardjohnny regenerativetranslationofhumanbloodvesselderivedmscprecursors AT chenchienwen regenerativetranslationofhumanbloodvesselderivedmscprecursors AT peaultbruno regenerativetranslationofhumanbloodvesselderivedmscprecursors |