Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varyin...

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Bibliographic Details
Main Authors: Zheng, Shu, Goldblum, Rebecca R., Gelwan, Noah A., Ramos, Daniel M., Nolan, Michael A., Wang, Karen, Weng, Feng-Ju, Lin, Yingxi, Wilson, Matthew A., Brown, Emery N., Van Dort, Christa, Zachs, Daniel, Kenny, Jonathan Dillion
Other Authors: Institute for Medical Engineering and Science
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/98021
https://orcid.org/0000-0002-7002-1275
https://orcid.org/0000-0003-2668-7819
https://orcid.org/0000-0003-3745-3217
https://orcid.org/0000-0002-9615-3233
https://orcid.org/0000-0001-7149-3584
https://orcid.org/0000-0001-7734-6008
Description
Summary:Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.

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