Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep
Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varyin...
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2015
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| Online Access: | http://hdl.handle.net/1721.1/98021 https://orcid.org/0000-0002-7002-1275 https://orcid.org/0000-0003-2668-7819 https://orcid.org/0000-0003-3745-3217 https://orcid.org/0000-0002-9615-3233 https://orcid.org/0000-0001-7149-3584 https://orcid.org/0000-0001-7734-6008 |
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| author | Zheng, Shu Goldblum, Rebecca R. Gelwan, Noah A. Ramos, Daniel M. Nolan, Michael A. Wang, Karen Weng, Feng-Ju Lin, Yingxi Wilson, Matthew A. Brown, Emery N. Van Dort, Christa Zachs, Daniel Kenny, Jonathan Dillion |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Zheng, Shu Goldblum, Rebecca R. Gelwan, Noah A. Ramos, Daniel M. Nolan, Michael A. Wang, Karen Weng, Feng-Ju Lin, Yingxi Wilson, Matthew A. Brown, Emery N. Van Dort, Christa Zachs, Daniel Kenny, Jonathan Dillion |
| author_sort | Zheng, Shu |
| collection | MIT |
| description | Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep. |
| first_indexed | 2024-09-23T09:04:04Z |
| format | Article |
| id | mit-1721.1/98021 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:04:04Z |
| publishDate | 2015 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/980212022-09-26T10:13:34Z Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep Zheng, Shu Goldblum, Rebecca R. Gelwan, Noah A. Ramos, Daniel M. Nolan, Michael A. Wang, Karen Weng, Feng-Ju Lin, Yingxi Wilson, Matthew A. Brown, Emery N. Van Dort, Christa Zachs, Daniel Kenny, Jonathan Dillion Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Lincoln Laboratory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Picower Institute for Learning and Memory Van Dort, Christa Zachs, Daniel Kenny, Jonathan Dillion Zheng, Shu Goldblum, Rebecca R. Gelwan, Noah A. Ramos, Daniel M. Nolan, Michael A. Wang, Karen Weng, Feng-Ju Lin, Yingxi Wilson, Matthew A. Brown, Emery N. Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep. National Institutes of Health (U.S.) (Grant DP1-OD003646) National Institutes of Health (U.S.) (Grant TR01-GM104948) National Institutes of Health (U.S.) (Grant T32-HL07901) Massachusetts General Hospital (Executive Committee on Research Fellowship) Massachusetts General Hospital. Dept. of Anesthesia, Critical Care, and Pain Medicine 2015-08-05T13:17:21Z 2015-08-05T13:17:21Z 2015-01 2014-09 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/98021 Van Dort, Christa J., Daniel P. Zachs, Jonathan D. Kenny, Shu Zheng, Rebecca R. Goldblum, Noah A. Gelwan, Daniel M. Ramos, et al. “Optogenetic Activation of Cholinergic Neurons in the PPT or LDT Induces REM Sleep.” Proc Natl Acad Sci USA 112, no. 2 (December 29, 2014): 584–589. https://orcid.org/0000-0002-7002-1275 https://orcid.org/0000-0003-2668-7819 https://orcid.org/0000-0003-3745-3217 https://orcid.org/0000-0002-9615-3233 https://orcid.org/0000-0001-7149-3584 https://orcid.org/0000-0001-7734-6008 en_US http://dx.doi.org/10.1073/pnas.1423136112 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) National Academy of Sciences (U.S.) |
| spellingShingle | Zheng, Shu Goldblum, Rebecca R. Gelwan, Noah A. Ramos, Daniel M. Nolan, Michael A. Wang, Karen Weng, Feng-Ju Lin, Yingxi Wilson, Matthew A. Brown, Emery N. Van Dort, Christa Zachs, Daniel Kenny, Jonathan Dillion Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep |
| title | Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep |
| title_full | Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep |
| title_fullStr | Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep |
| title_full_unstemmed | Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep |
| title_short | Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep |
| title_sort | optogenetic activation of cholinergic neurons in the ppt or ldt induces rem sleep |
| url | http://hdl.handle.net/1721.1/98021 https://orcid.org/0000-0002-7002-1275 https://orcid.org/0000-0003-2668-7819 https://orcid.org/0000-0003-3745-3217 https://orcid.org/0000-0002-9615-3233 https://orcid.org/0000-0001-7149-3584 https://orcid.org/0000-0001-7734-6008 |
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