Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment

Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment

Perturbations in fast-spiking parvalbumin (PV) interneurons are hypothesized to be a major component of various neuropsychiatric disorders; however, the mechanisms regulating PV interneurons remain mostly unknown. Recently, cyclin-dependent kinase 5 (Cdk5) has been shown to function as a major regul...

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Bibliographic Details
Main Authors: Rudenko, Andrii, Seo, Jinsoo, Hu, Ji, Su, Susan C., de Anda, Froylan Calderon, Durak, Omer, Ericsson, Maria, Carlen, Marie, Tsai, Li-Huei
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Society for Neuroscience 2015
Online Access:http://hdl.handle.net/1721.1/98036
https://orcid.org/0000-0003-1262-0592
https://orcid.org/0000-0001-8426-6188

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