The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations
Background and Methods It is important to ensure that blood flow is modelled accurately in numerical studies of arteries featuring drug-eluting stents due to the significant proportion of drug transport from the stent into the arterial wall which is flow-mediated. Modelling blood is complicated, ho...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Public Library of Science
2015
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| Online Access: | http://hdl.handle.net/1721.1/98172 https://orcid.org/0000-0002-7832-7156 https://orcid.org/0000-0002-2890-2319 |
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| author | Vijayaratnam, Pujith R. S. O’Brien, Caroline C. Reizes, John A. Barber, Tracie J. Edelman, Elazer R. |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Vijayaratnam, Pujith R. S. O’Brien, Caroline C. Reizes, John A. Barber, Tracie J. Edelman, Elazer R. |
| author_sort | Vijayaratnam, Pujith R. S. |
| collection | MIT |
| description | Background and Methods
It is important to ensure that blood flow is modelled accurately in numerical studies of arteries featuring drug-eluting stents due to the significant proportion of drug transport from the stent into the arterial wall which is flow-mediated. Modelling blood is complicated, however, by variations in blood rheological behaviour between individuals, blood’s complex near-wall behaviour, and the large number of rheological models which have been proposed. In this study, a series of steady-state computational fluid dynamics analyses were performed in which the traditional Newtonian model was compared against a range of non-Newtonian models. The impact of these rheological models was elucidated through comparisons of haemodynamic flow details and drug transport behaviour at various blood flow rates.
Results
Recirculation lengths were found to reduce by as much as 24% with the inclusion of a non-Newtonian rheological model. Another model possessing the viscosity and density of blood plasma was also implemented to account for near-wall red blood cell losses and yielded recirculation length increases of up to 59%. However, the deviation from the average drug concentration in the tissue obtained with the Newtonian model was observed to be less than 5% in all cases except one. Despite the small sensitivity to the effects of viscosity variations, the spatial distribution of drug matter in the tissue was found to be significantly affected by rheological model selection.
Conclusions/Significance
These results may be used to guide blood rheological model selection in future numerical studies. The clinical significance of these results is that they convey that the magnitude of drug uptake in stent-based drug delivery is relatively insensitive to individual variations in blood rheology. Furthermore, the finding that flow separation regions formed downstream of the stent struts diminish drug uptake may be of interest to device designers. |
| first_indexed | 2024-09-23T17:10:41Z |
| format | Article |
| id | mit-1721.1/98172 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:10:41Z |
| publishDate | 2015 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/981722022-09-30T00:11:48Z The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations Vijayaratnam, Pujith R. S. O’Brien, Caroline C. Reizes, John A. Barber, Tracie J. Edelman, Elazer R. Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Center for Biomedical Engineering O’Brien, Caroline C. Edelman, Elazer R. Background and Methods It is important to ensure that blood flow is modelled accurately in numerical studies of arteries featuring drug-eluting stents due to the significant proportion of drug transport from the stent into the arterial wall which is flow-mediated. Modelling blood is complicated, however, by variations in blood rheological behaviour between individuals, blood’s complex near-wall behaviour, and the large number of rheological models which have been proposed. In this study, a series of steady-state computational fluid dynamics analyses were performed in which the traditional Newtonian model was compared against a range of non-Newtonian models. The impact of these rheological models was elucidated through comparisons of haemodynamic flow details and drug transport behaviour at various blood flow rates. Results Recirculation lengths were found to reduce by as much as 24% with the inclusion of a non-Newtonian rheological model. Another model possessing the viscosity and density of blood plasma was also implemented to account for near-wall red blood cell losses and yielded recirculation length increases of up to 59%. However, the deviation from the average drug concentration in the tissue obtained with the Newtonian model was observed to be less than 5% in all cases except one. Despite the small sensitivity to the effects of viscosity variations, the spatial distribution of drug matter in the tissue was found to be significantly affected by rheological model selection. Conclusions/Significance These results may be used to guide blood rheological model selection in future numerical studies. The clinical significance of these results is that they convey that the magnitude of drug uptake in stent-based drug delivery is relatively insensitive to individual variations in blood rheology. Furthermore, the finding that flow separation regions formed downstream of the stent struts diminish drug uptake may be of interest to device designers. National Institutes of Health (U.S.) (Grant R01 GM49039) 2015-08-21T12:13:41Z 2015-08-21T12:13:41Z 2015-06 2015-01 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/98172 Vijayaratnam, Pujith R. S., Caroline C. O’Brien, John A. Reizes, Tracie J. Barber, and Elazer R. Edelman. “The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations.” Edited by Victor M Ugaz. PLoS ONE 10, no. 6 (June 12, 2015): e0128178. https://orcid.org/0000-0002-7832-7156 https://orcid.org/0000-0002-2890-2319 en_US http://dx.doi.org/10.1371/journal.pone.0128178 PLOS ONE Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science Public Library of Science |
| spellingShingle | Vijayaratnam, Pujith R. S. O’Brien, Caroline C. Reizes, John A. Barber, Tracie J. Edelman, Elazer R. The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations |
| title | The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations |
| title_full | The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations |
| title_fullStr | The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations |
| title_full_unstemmed | The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations |
| title_short | The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations |
| title_sort | impact of blood rheology on drug transport in stented arteries steady simulations |
| url | http://hdl.handle.net/1721.1/98172 https://orcid.org/0000-0002-7832-7156 https://orcid.org/0000-0002-2890-2319 |
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