Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function
Since the discovery of nerve growth factor (NGF) more than a half century ago (Levi-Montalcini and Cohen, 1960), the prototypic neurotrophin family has included brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Neurotrophins bind to the Trk family of recepto...
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| Format: | Article |
| Language: | en_US |
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Frontiers Research Foundation
2015
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| Online Access: | http://hdl.handle.net/1721.1/98181 https://orcid.org/0000-0003-2268-0863 |
| _version_ | 1826207330248687616 |
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| author | Yoshii, Akira Constantine-Paton, Martha Ip, Nancy Y. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Yoshii, Akira Constantine-Paton, Martha Ip, Nancy Y. |
| author_sort | Yoshii, Akira |
| collection | MIT |
| description | Since the discovery of nerve growth factor (NGF) more than a half century ago (Levi-Montalcini and Cohen, 1960), the prototypic neurotrophin family has included brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Neurotrophins bind to the Trk family of receptors, as well as the p75 receptor, to activate multiple intracellular signaling cascades (reviewed by Reichardt, 2006). BDNF receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. The pathway mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays critical roles in circuit development and maintenance. In addition to BDNF, many studies have identified other “growth” or signaling factors in the CNS that play important roles in the development, maintenance, and control of synaptic and circuit function. However, details of the intracellular signaling systems downstream of these events are frequently unexplored. In this Research Topic, we have collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. |
| first_indexed | 2024-09-23T13:47:57Z |
| format | Article |
| id | mit-1721.1/98181 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:47:57Z |
| publishDate | 2015 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/981812022-10-01T17:12:02Z Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function Yoshii, Akira Constantine-Paton, Martha Ip, Nancy Y. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Constantine-Paton, Martha Since the discovery of nerve growth factor (NGF) more than a half century ago (Levi-Montalcini and Cohen, 1960), the prototypic neurotrophin family has included brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Neurotrophins bind to the Trk family of receptors, as well as the p75 receptor, to activate multiple intracellular signaling cascades (reviewed by Reichardt, 2006). BDNF receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. The pathway mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays critical roles in circuit development and maintenance. In addition to BDNF, many studies have identified other “growth” or signaling factors in the CNS that play important roles in the development, maintenance, and control of synaptic and circuit function. However, details of the intracellular signaling systems downstream of these events are frequently unexplored. In this Research Topic, we have collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. National Institutes of Health (U.S.) (Grant 5R01EY006039-27) National Institutes of Health (U.S.) (Grant 5R01EY014074-15) 2015-08-21T14:42:34Z 2015-08-21T14:42:34Z 2015-06 2015-05 Article http://purl.org/eprint/type/JournalArticle 1663-3563 http://hdl.handle.net/1721.1/98181 Yoshii, Akira, Martha Constantine-Paton, and Nancy Y. Ip. “Editorial: Cell and Molecular Signaling, and Transport Pathways Involved in Growth Factor Control of Synaptic Development and Function.” Frontiers in Synaptic Neuroscience 7 (June 4, 2015). https://orcid.org/0000-0003-2268-0863 en_US http://dx.doi.org/10.3389/fnsyn.2015.00008 Frontiers in Synaptic Neuroscience Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Research Foundation Frontiers Research Foundation |
| spellingShingle | Yoshii, Akira Constantine-Paton, Martha Ip, Nancy Y. Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title | Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_full | Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_fullStr | Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_full_unstemmed | Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_short | Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_sort | editorial cell and molecular signaling and transport pathways involved in growth factor control of synaptic development and function |
| url | http://hdl.handle.net/1721.1/98181 https://orcid.org/0000-0003-2268-0863 |
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