Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific...
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/98345 |
| _version_ | 1826200343846846464 |
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| author | Lander, Eric Steven |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lander, Eric Steven |
| author_sort | Lander, Eric Steven |
| collection | MIT |
| description | The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci. |
| first_indexed | 2024-09-23T11:35:00Z |
| format | Article |
| id | mit-1721.1/98345 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:35:00Z |
| publishDate | 2015 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/983452022-09-27T20:30:06Z Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication Lander, Eric Steven Massachusetts Institute of Technology. Department of Biology Lander, Eric S. Lander, Eric S. The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci. National Human Genome Research Institute (U.S.) (Grant U54 HG003067) 2015-09-03T13:02:14Z 2015-09-03T13:02:14Z 2014-08 2014-03 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/98345 Carneiro, M., C.-J. Rubin, F. Di Palma, F. W. Albert, J. Alfoldi, A. M. Barrio, G. Pielberg, et al. “Rabbit Genome Analysis Reveals a Polygenic Basis for Phenotypic Change During Domestication.” Science 345, no. 6200 (August 28, 2014): 1074–1079. en_US http://dx.doi.org/10.1126/science.1253714 Science Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) Lander |
| spellingShingle | Lander, Eric Steven Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication |
| title | Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication |
| title_full | Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication |
| title_fullStr | Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication |
| title_full_unstemmed | Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication |
| title_short | Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication |
| title_sort | rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication |
| url | http://hdl.handle.net/1721.1/98345 |
| work_keys_str_mv | AT landerericsteven rabbitgenomeanalysisrevealsapolygenicbasisforphenotypicchangeduringdomestication |