Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale
X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have de...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2015
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| Online Access: | http://hdl.handle.net/1721.1/98439 https://orcid.org/0000-0002-5770-1241 |
| _version_ | 1811078861056638976 |
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| author | Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv |
| author_sort | Sung, Yongjin |
| collection | MIT |
| description | X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool by combining a numerical anthropomorphic phantom defined with non-uniform rational B-splines (NURBS) and a wave optics-based simulator that can accurately capture the phase-contrast signal from a human-scaled numerical phantom. Using a synchrotron-based, high-performance XPCI system, we provide qualitative comparison between simulated and experimental images. Our tool can be used to simulate the performance of XPCI on various disease entities and compare proposed XPCI systems in an unbiased manner. |
| first_indexed | 2024-09-23T11:06:31Z |
| format | Article |
| id | mit-1721.1/98439 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:06:31Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/984392022-10-01T01:16:33Z Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv Harvard University--MIT Division of Health Sciences and Technology Pan, Adam X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool by combining a numerical anthropomorphic phantom defined with non-uniform rational B-splines (NURBS) and a wave optics-based simulator that can accurately capture the phase-contrast signal from a human-scaled numerical phantom. Using a synchrotron-based, high-performance XPCI system, we provide qualitative comparison between simulated and experimental images. Our tool can be used to simulate the performance of XPCI on various disease entities and compare proposed XPCI systems in an unbiased manner. United States. Defense Advanced Research Projects Agency. AXiS Program (Grant N66001-11-4204, P.R. 1300217190) Japan. Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research 18206011) 2015-09-10T16:19:21Z 2015-09-10T16:19:21Z 2015-07 2015-03 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/98439 Sung, Yongjin, W. Paul Segars, Adam Pan, Masami Ando, Colin J. R. Sheppard, and Rajiv Gupta. “Realistic Wave-Optics Simulation of X-Ray Phase-Contrast Imaging at a Human Scale.” Scientific Reports 5 (July 14, 2015): 12011. https://orcid.org/0000-0002-5770-1241 en_US http://dx.doi.org/10.1038/srep12011 Scientific Reports Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature Publishing Group |
| spellingShingle | Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
| title | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
| title_full | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
| title_fullStr | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
| title_full_unstemmed | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
| title_short | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
| title_sort | realistic wave optics simulation of x ray phase contrast imaging at a human scale |
| url | http://hdl.handle.net/1721.1/98439 https://orcid.org/0000-0002-5770-1241 |
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