Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage
Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve hemostasis, these approaches are difficult to employ on the battlefield and cannot...
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/98531 https://orcid.org/0000-0002-7272-7140 https://orcid.org/0000-0002-0193-7378 https://orcid.org/0000-0001-8323-2779 https://orcid.org/0000-0002-0284-0201 |
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| author | Assmann, Alexander Paul, Arghya Khademhosseini, Ali Avery, Reginald Keith Gaharwar, Akhilesh McKinley, Gareth H Olsen, Bradley D |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Assmann, Alexander Paul, Arghya Khademhosseini, Ali Avery, Reginald Keith Gaharwar, Akhilesh McKinley, Gareth H Olsen, Bradley D |
| author_sort | Assmann, Alexander |
| collection | MIT |
| description | Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve hemostasis, these approaches are difficult to employ on the battlefield and cannot be used for incompressible wounds. Here, we present shear-thinning nanocomposite hydrogels composed of synthetic silicate nanoplatelets and gelatin as injectable hemostatic agents. These materials are demonstrated to decrease in vitro blood clotting times by 77%, and to form stable clot-gel systems. In vivo tests indicated that the nanocomposites are biocompatible and capable of promoting hemostasis in an otherwise lethal liver laceration. The combination of injectability, rapid mechanical recovery, physiological stability, and the ability to promote coagulation result in a hemostat for treating incompressible wounds in out-of-hospital, emergency conditions. |
| first_indexed | 2024-09-23T08:23:11Z |
| format | Article |
| id | mit-1721.1/98531 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:23:11Z |
| publishDate | 2015 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/985312022-09-30T09:12:36Z Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage Assmann, Alexander Paul, Arghya Khademhosseini, Ali Avery, Reginald Keith Gaharwar, Akhilesh McKinley, Gareth H Olsen, Bradley D Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Gaharwar, Akhilesh K. Avery, Reginald Keith McKinley, Gareth H. Khademhosseini, Ali Olsen, Bradley D. Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve hemostasis, these approaches are difficult to employ on the battlefield and cannot be used for incompressible wounds. Here, we present shear-thinning nanocomposite hydrogels composed of synthetic silicate nanoplatelets and gelatin as injectable hemostatic agents. These materials are demonstrated to decrease in vitro blood clotting times by 77%, and to form stable clot-gel systems. In vivo tests indicated that the nanocomposites are biocompatible and capable of promoting hemostasis in an otherwise lethal liver laceration. The combination of injectability, rapid mechanical recovery, physiological stability, and the ability to promote coagulation result in a hemostat for treating incompressible wounds in out-of-hospital, emergency conditions. United States. Army Research Office (Contract W911NF-13-D-0001) National Institutes of Health (U.S.) (Interdepartmental Biotechnology Training Program NIH/NIGMS 5T32GM008334) 2015-09-16T16:24:40Z 2015-09-16T16:24:40Z 2014-09 2014-07 Article http://purl.org/eprint/type/JournalArticle 1936-0851 1936-086X http://hdl.handle.net/1721.1/98531 Gaharwar, Akhilesh K., Reginald K. Avery, Alexander Assmann, Arghya Paul, Gareth H. McKinley, Ali Khademhosseini, and Bradley D. Olsen. “Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage.” ACS Nano 8, no. 10 (October 28, 2014): 9833–42. © 2014 American Chemical Society https://orcid.org/0000-0002-7272-7140 https://orcid.org/0000-0002-0193-7378 https://orcid.org/0000-0001-8323-2779 https://orcid.org/0000-0002-0284-0201 en_US http://dx.doi.org/10.1021/nn503719n ACS Nano Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Assmann, Alexander Paul, Arghya Khademhosseini, Ali Avery, Reginald Keith Gaharwar, Akhilesh McKinley, Gareth H Olsen, Bradley D Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage |
| title | Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage |
| title_full | Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage |
| title_fullStr | Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage |
| title_full_unstemmed | Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage |
| title_short | Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage |
| title_sort | shear thinning nanocomposite hydrogels for the treatment of hemorrhage |
| url | http://hdl.handle.net/1721.1/98531 https://orcid.org/0000-0002-7272-7140 https://orcid.org/0000-0002-0193-7378 https://orcid.org/0000-0001-8323-2779 https://orcid.org/0000-0002-0284-0201 |
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