PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity
Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity. Synaptic glutamatergic receptors including AMPA receptors and NMDA receptors (AMPARs and NMDARs) are embedded in the...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/98845 https://orcid.org/0000-0003-0096-2288 |
| _version_ | 1826212985447645184 |
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| author | Xu, Weifeng |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Xu, Weifeng |
| author_sort | Xu, Weifeng |
| collection | MIT |
| description | Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity. Synaptic glutamatergic receptors including AMPA receptors and NMDA receptors (AMPARs and NMDARs) are embedded in the postsynaptic density, a highly organized protein network. Overwhelming data have shown that PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs), a major family of scaffold proteins at glutamatergic synapses, regulate basal synaptic AMPAR function and trafficking. It is now clear that PSD-MAGUKs have multifaceted functions in regulating both basal synaptic transmission and synaptic plasticity. Here we discuss recent advancements in understanding the roles of PSD-95 and other family members of PSD-MAGUKs in synaptic plasticity, both as an anchoring protein for synaptic AMPARs and as a signaling scaffold for mediating the interaction of the signaling complex and NMDARs. |
| first_indexed | 2024-09-23T15:41:17Z |
| format | Article |
| id | mit-1721.1/98845 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:41:17Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/988452022-09-29T15:29:10Z PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity Xu, Weifeng Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Xu, Weifeng Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity. Synaptic glutamatergic receptors including AMPA receptors and NMDA receptors (AMPARs and NMDARs) are embedded in the postsynaptic density, a highly organized protein network. Overwhelming data have shown that PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs), a major family of scaffold proteins at glutamatergic synapses, regulate basal synaptic AMPAR function and trafficking. It is now clear that PSD-MAGUKs have multifaceted functions in regulating both basal synaptic transmission and synaptic plasticity. Here we discuss recent advancements in understanding the roles of PSD-95 and other family members of PSD-MAGUKs in synaptic plasticity, both as an anchoring protein for synaptic AMPARs and as a signaling scaffold for mediating the interaction of the signaling complex and NMDARs. National Institute of Mental Health (U.S.) (Grant MH080310) 2015-09-18T17:44:50Z 2015-09-18T17:44:50Z 2011-03 Article http://purl.org/eprint/type/JournalArticle 09594388 http://hdl.handle.net/1721.1/98845 Xu, Weifeng. “PSD-95-like Membrane Associated Guanylate Kinases (PSD-MAGUKs) and Synaptic Plasticity.” Current Opinion in Neurobiology 21, no. 2 (April 2011): 306–12. https://orcid.org/0000-0003-0096-2288 en_US http://dx.doi.org/10.1016/j.conb.2011.03.001 Current Opinion in Neurobiology Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Xu, Weifeng PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity |
| title | PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity |
| title_full | PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity |
| title_fullStr | PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity |
| title_full_unstemmed | PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity |
| title_short | PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity |
| title_sort | psd 95 like membrane associated guanylate kinases psd maguks and synaptic plasticity |
| url | http://hdl.handle.net/1721.1/98845 https://orcid.org/0000-0003-0096-2288 |
| work_keys_str_mv | AT xuweifeng psd95likemembraneassociatedguanylatekinasespsdmaguksandsynapticplasticity |