Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch
A 30-year-old white man with established Barrett’s esophagus (BE) and continued symptoms of chronic severe heartburn, persistent cough, throat irritation, and asthma was referred for surveillance EGD at the VA Boston Healthcare System. During retraction of the endoscope, a pink circular lesion (A) w...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/98867 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 |
| _version_ | 1826208081404493824 |
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| author | Zhou, Chao Kirtane, Tejas Tsai, Tsung-Han Lee, Hsiang-Chieh Adler, Desmond C. Schmitt, Joseph Huang, Qin Fujimoto, James G. Mashimo, Hiroshi |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Zhou, Chao Kirtane, Tejas Tsai, Tsung-Han Lee, Hsiang-Chieh Adler, Desmond C. Schmitt, Joseph Huang, Qin Fujimoto, James G. Mashimo, Hiroshi |
| author_sort | Zhou, Chao |
| collection | MIT |
| description | A 30-year-old white man with established Barrett’s esophagus (BE) and continued symptoms of chronic severe heartburn, persistent cough, throat irritation, and asthma was referred for surveillance EGD at the VA Boston Healthcare System. During retraction of the endoscope, a pink circular lesion (A) was observed under white light endoscopy in the upper esophagus (spanning 20–22 cm from the incisors). Three-dimensional endoscopic optical coherence tomography (OCT) images were obtained of the region under direct visualization with white light by passing the probe through the standard accessory channel. An en face projection image (B) at 400-μm depth underneath the tissue surface showed columnar epithelium consistent with a cervical inlet patch (CIP) and surrounding normal squamous epithelium (SE). Cross-sectional OCT images along the probe pull-back direction (C) and the probe rotation direction (D and F) clearly demonstrated columnar and squamous epithelium in the CIP region and the surrounding esophagus, respectively. Biopsy specimens taken from the imaged lesion confirmed the finding of CIP. The OCT features matched representative hematoxylin and eosin histology (E and G). Both esophageal and extraesophageal symptoms responded to increased antacid therapy. |
| first_indexed | 2024-09-23T14:00:10Z |
| format | Article |
| id | mit-1721.1/98867 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:00:10Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/988672022-09-28T17:37:58Z Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch Zhou, Chao Kirtane, Tejas Tsai, Tsung-Han Lee, Hsiang-Chieh Adler, Desmond C. Schmitt, Joseph Huang, Qin Fujimoto, James G. Mashimo, Hiroshi Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Zhou, Chao Tsai, Tsung-Han Lee, Hsiang-Chieh Fujimoto, James G. A 30-year-old white man with established Barrett’s esophagus (BE) and continued symptoms of chronic severe heartburn, persistent cough, throat irritation, and asthma was referred for surveillance EGD at the VA Boston Healthcare System. During retraction of the endoscope, a pink circular lesion (A) was observed under white light endoscopy in the upper esophagus (spanning 20–22 cm from the incisors). Three-dimensional endoscopic optical coherence tomography (OCT) images were obtained of the region under direct visualization with white light by passing the probe through the standard accessory channel. An en face projection image (B) at 400-μm depth underneath the tissue surface showed columnar epithelium consistent with a cervical inlet patch (CIP) and surrounding normal squamous epithelium (SE). Cross-sectional OCT images along the probe pull-back direction (C) and the probe rotation direction (D and F) clearly demonstrated columnar and squamous epithelium in the CIP region and the surrounding esophagus, respectively. Biopsy specimens taken from the imaged lesion confirmed the finding of CIP. The OCT features matched representative hematoxylin and eosin histology (E and G). Both esophageal and extraesophageal symptoms responded to increased antacid therapy. United States. Veterans Administration National Institutes of Health (U.S.) (Grant R01-CA75289-14) United States. Air Force Office of Scientific Research (Contract FA9550-10-1-0063) United States. Dept. of Defense. Medical Free Electron Laser Program (Contract FA9550-10-1-0551) MIT/Center for Integration of Medicine and Innovative Technology (Medical Engineering Fellowship) National Science Council of Taiwan (Taiwan Merit Scholarship) 2015-09-22T18:12:18Z 2015-09-22T18:12:18Z 2012-02 Article http://purl.org/eprint/type/JournalArticle 00165107 http://hdl.handle.net/1721.1/98867 Zhou, Chao, Tejas Kirtane, Tsung-Han Tsai, Hsiang-Chieh Lee, Desmond C. Adler, Joseph Schmitt, Qin Huang, James G. Fujimoto, and Hiroshi Mashimo. “Three-Dimensional Endoscopic Optical Coherence Tomography Imaging of Cervical Inlet Patch.” Gastrointestinal Endoscopy 75, no. 3 (March 2012): 675–677. https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 en_US http://dx.doi.org/10.1016/j.gie.2011.11.009 Gastrointestinal Endoscopy Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Zhou, Chao Kirtane, Tejas Tsai, Tsung-Han Lee, Hsiang-Chieh Adler, Desmond C. Schmitt, Joseph Huang, Qin Fujimoto, James G. Mashimo, Hiroshi Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch |
| title | Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch |
| title_full | Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch |
| title_fullStr | Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch |
| title_full_unstemmed | Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch |
| title_short | Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch |
| title_sort | three dimensional endoscopic optical coherence tomography imaging of cervical inlet patch |
| url | http://hdl.handle.net/1721.1/98867 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 |
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