Engineering a comet-based platform for specific, sensitive, and high throughput assessment of multiple DNA repair pathways in humans

Engineering a comet-based platform for specific, sensitive, and high throughput assessment of multiple DNA repair pathways in humans

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2015.

Manylion Llyfryddiaeth
Prif Awdur:	Ge, Jing, Ph. D. Massachusetts Institute of Technology
Awduron Eraill:	Bevin P. Engelward.
Fformat:	Traethawd Ymchwil
Iaith:	eng
Cyhoeddwyd:	Massachusetts Institute of Technology 2015
Pynciau:	Biological Engineering.
Mynediad Ar-lein:	http://hdl.handle.net/1721.1/99054

Eitemau Tebyg

Micropatterned comet assay enables high throughput and sensitive DNA damage quantification
gan: Engelward, B. P., et al.
Cyhoeddwyd: (2016)

Analysis of NusA's roles in DNA repair and damage tolerance pathways in Escherichia coli
gan: Zhao, Yimin, S.M. Massachusetts Institute of Technology
Cyhoeddwyd: (2015)

A novel role for the transcriptional modulator NusA in DNA repair/damage tolerance pathways in Escherichia coli
gan: Cohen, Susan E., Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2009)

MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum
gan: Xiong, Aoli, et al.
Cyhoeddwyd: (2023)

CometChip enables parallel analysis of multiple DNA repair activities
gan: Ge, Jing, et al.
Cyhoeddwyd: (2021)

Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates
gan: Ngo, Le P, et al.
Cyhoeddwyd: (2020)

Engineering a single cell microarray platform for high throughput DNA damage and repair analysis
gan: Weingeist, David McGregor
Cyhoeddwyd: (2012)

CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells
gan: Ge, Jing, et al.
Cyhoeddwyd: (2014)

High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology
gan: Watson, Christa, et al.
Cyhoeddwyd: (2015)

High throughput microfluidic technologies for cell separation and single-cell analysis
gan: Wu, Lidan, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2016)

The development and validation of EpiComet-Chip, a modified high-throughput comet assay for the assessment of DNA methylation status
gan: Townsend, Todd A., et al.
Cyhoeddwyd: (2018)

MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum
gan: Xiong, Aoli, et al.
Cyhoeddwyd: (2022)

Developmental regulation of DNA replication initiation in Drosophila
gan: Xie, Fang, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2008)

High-throughput vertebrate total analysis/screening platform
gan: Chang, Tsung-Yao, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2013)

Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Multiple Mouse Tissues
gan: Owiti, Norah A., et al.
Cyhoeddwyd: (2022)

Regulation of DNA replication and the replication initiator, DnaA, in Bacillus subtilis
gan: Anderson, Mary E.,Ph. D.(Mary Elizabeth)Massachusetts Institute of Technology.
Cyhoeddwyd: (2019)

The analysis of DNA interstrand cross-links and their repair by the modified comet assay
gan: Castle, L, et al.
Cyhoeddwyd: (2020)

Studies of amino acid sensing by the mTORC 1 pathway
gan: Wang, Shuyu, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2017)

A novel DNA damage quantification platform enables high throughput screening for genes that impact DNA double strand breaks
gan: Tay, Ian Jun Jie.
Cyhoeddwyd: (2019)

Tuning strength and specificity in the N-end rule
gan: Wang, Kevin H., Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2009)

Rational design to control multipotent stromal cell migration for applications in bone tissue engineering and injury repair
gan: Wu, Shan, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2011)

Exploring the mutagenic consequences of inflammation and DNA damage
gan: Kay, Jennifer Elizabeth, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2018)

Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
gan: Romero, Rodrigo,Ph. D.Massachusetts Institute of Technology.
Cyhoeddwyd: (2019)

Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
gan: Wang, Yang, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2017)

Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
gan: Lu, Diana, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2014)

Bayesian network models of biological signaling pathways
gan: Sachs, Karen, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2007)

Genetic analysis of cGMP-dependent chemosensory signal transduction pathways in the detection of bacterial metabolites by C. elegans
gan: Park, Jaeseok,Ph.D.Massachusetts Institute of Technology.
Cyhoeddwyd: (2020)

Actions of aprataxin in multiple DNA repair pathways.
gan: Rass, U, et al.
Cyhoeddwyd: (2007)

Screening for inhibitors of and novel proteins within the homologous recombination DNA repair pathway
gan: Kingham, G
Cyhoeddwyd: (2012)

Next-generation sequencing as a tool for investigating the in vivo biological consequences of DNA lesions and its applications on the ethenoguanine, 8-oxoguanine and 1,3-butadiene-induced lesions
gan: Chang, Shiou-chi, Ph. D. Massachusetts Institute of Technology
Cyhoeddwyd: (2017)

Chilton's repair and tune-up guide : Maverick/Comet
gan: Chilton Book Company. Automotive Editorial Department
Cyhoeddwyd: (1974)

DNA repair and genomic instability in yeast aging
gan: Park, Peter Unnam, 1971-
Cyhoeddwyd: (2005)

Functional DNA repair capacity assays : a focus on base excision repair
gan: Chaim, Isaac Alexander
Cyhoeddwyd: (2016)

Comet/
gan: 419429 Sagan, Carl
Cyhoeddwyd: (1985)

Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?
gan: Satomi Kawaguchi, et al.
Cyhoeddwyd: (2010-01-01)

Using optical tweezers, single molecule fluorescence and the ZIF268 protein-DNA system to probe mechanotransduction mechanisms
gan: Lee, Peter, S.M. Massachusetts Institute of Technology
Cyhoeddwyd: (2006)

Studies of DNA repair and mutagenesis in Escherichia coli and Bacillus subtilis
gan: Smith, Bradley Theodore
Cyhoeddwyd: (2005)

Targeting DNA repair nucleases in cancer
gan: Henderson, LR
Cyhoeddwyd: (2023)

Physical organization of DNA by multiple non-specific DNA-binding modes of integration host factor (IHF)
gan: Lin, Jie, et al.
Cyhoeddwyd: (2013)