Functional specialization of ribosomes?
Ribosomes are highly conserved macromolecular machines that are responsible for protein synthesis in all living organisms. Work published in the past year has shown that changes to the ribosome core can affect the mechanism of translation initiation that is favored in the cell, which potentially lea...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/99128 https://orcid.org/0000-0003-2807-9657 |
| _version_ | 1826212985834569728 |
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| author | Gilbert, Wendy |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Gilbert, Wendy |
| author_sort | Gilbert, Wendy |
| collection | MIT |
| description | Ribosomes are highly conserved macromolecular machines that are responsible for protein synthesis in all living organisms. Work published in the past year has shown that changes to the ribosome core can affect the mechanism of translation initiation that is favored in the cell, which potentially leads to specific changes in the relative efficiencies with which different proteins are made. Here, I examine recent data from expression and proteomic studies that suggest that cells make slightly different ribosomes under different growth conditions, and discuss genetic evidence that such differences are functional. In particular, I argue that eukaryotic cells probably produce ribosomes that lack one or more core ribosomal proteins (RPs) under some conditions, and that core RPs contribute differentially to translation of distinct subpopulations of mRNAs. |
| first_indexed | 2024-09-23T15:41:17Z |
| format | Article |
| id | mit-1721.1/99128 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:41:17Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/991282022-10-02T03:24:38Z Functional specialization of ribosomes? Gilbert, Wendy Massachusetts Institute of Technology. Department of Biology Gilbert, Wendy Ribosomes are highly conserved macromolecular machines that are responsible for protein synthesis in all living organisms. Work published in the past year has shown that changes to the ribosome core can affect the mechanism of translation initiation that is favored in the cell, which potentially leads to specific changes in the relative efficiencies with which different proteins are made. Here, I examine recent data from expression and proteomic studies that suggest that cells make slightly different ribosomes under different growth conditions, and discuss genetic evidence that such differences are functional. In particular, I argue that eukaryotic cells probably produce ribosomes that lack one or more core ribosomal proteins (RPs) under some conditions, and that core RPs contribute differentially to translation of distinct subpopulations of mRNAs. 2015-10-02T16:49:49Z 2015-10-02T16:49:49Z 2011-01 Article http://purl.org/eprint/type/JournalArticle 09680004 http://hdl.handle.net/1721.1/99128 Gilbert, Wendy V. “Functional Specialization of Ribosomes?” Trends in Biochemical Sciences 36, no. 3 (March 2011): 127–132. https://orcid.org/0000-0003-2807-9657 en_US http://dx.doi.org/10.1016/j.tibs.2010.12.002 Trends in Biochemical Sciences Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Gilbert, Wendy Functional specialization of ribosomes? |
| title | Functional specialization of ribosomes? |
| title_full | Functional specialization of ribosomes? |
| title_fullStr | Functional specialization of ribosomes? |
| title_full_unstemmed | Functional specialization of ribosomes? |
| title_short | Functional specialization of ribosomes? |
| title_sort | functional specialization of ribosomes |
| url | http://hdl.handle.net/1721.1/99128 https://orcid.org/0000-0003-2807-9657 |
| work_keys_str_mv | AT gilbertwendy functionalspecializationofribosomes |