Formation of mammalian erythrocytes: chromatin condensation and enucleation
In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to mammals. Enucleation has critical physiological an...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/99166 https://orcid.org/0000-0002-7029-7415 |
| _version_ | 1810997111463870464 |
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| author | Ji, Peng Murata-Hori, Maki Lodish, Harvey F |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Ji, Peng Murata-Hori, Maki Lodish, Harvey F |
| author_sort | Ji, Peng |
| collection | MIT |
| description | In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to mammals. Enucleation has critical physiological and evolutionary significance in that it allows an elevation of hemoglobin levels in the blood and also gives red cells their flexible biconcave shape. Recent experiments reveal that enucleation involves multiple molecular and cellular pathways that include histone deacetylation, actin polymerization, cytokinesis, cell–matrix interactions, specific microRNAs and vesicle trafficking; many evolutionarily conserved proteins and genes have been recruited to participate in this uniquely mammalian process. In this review, we discuss recent advances in mammalian erythroblast chromatin condensation and enucleation, and conclude with our perspectives on future studies. |
| first_indexed | 2024-09-23T14:23:52Z |
| format | Article |
| id | mit-1721.1/99166 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:23:52Z |
| publishDate | 2015 |
| publisher | Elsevier |
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| spelling | mit-1721.1/991662022-09-29T09:12:25Z Formation of mammalian erythrocytes: chromatin condensation and enucleation Ji, Peng Murata-Hori, Maki Lodish, Harvey F Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Lodish, Harvey F. In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to mammals. Enucleation has critical physiological and evolutionary significance in that it allows an elevation of hemoglobin levels in the blood and also gives red cells their flexible biconcave shape. Recent experiments reveal that enucleation involves multiple molecular and cellular pathways that include histone deacetylation, actin polymerization, cytokinesis, cell–matrix interactions, specific microRNAs and vesicle trafficking; many evolutionarily conserved proteins and genes have been recruited to participate in this uniquely mammalian process. In this review, we discuss recent advances in mammalian erythroblast chromatin condensation and enucleation, and conclude with our perspectives on future studies. National Institutes of Health (U.S.) (Grant P01 HL 32262) Amgen Inc. (Research Grant) 2015-10-06T19:01:37Z 2015-10-06T19:01:37Z 2011-05 Article http://purl.org/eprint/type/JournalArticle 09628924 http://hdl.handle.net/1721.1/99166 Ji, Peng, Maki Murata-Hori, and Harvey F. Lodish. “Formation of Mammalian Erythrocytes: Chromatin Condensation and Enucleation.” Trends in Cell Biology 21, no. 7 (July 2011): 409–415. https://orcid.org/0000-0002-7029-7415 en_US http://dx.doi.org/10.1016/j.tcb.2011.04.003 Trends in Cell Biology Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Ji, Peng Murata-Hori, Maki Lodish, Harvey F Formation of mammalian erythrocytes: chromatin condensation and enucleation |
| title | Formation of mammalian erythrocytes: chromatin condensation and enucleation |
| title_full | Formation of mammalian erythrocytes: chromatin condensation and enucleation |
| title_fullStr | Formation of mammalian erythrocytes: chromatin condensation and enucleation |
| title_full_unstemmed | Formation of mammalian erythrocytes: chromatin condensation and enucleation |
| title_short | Formation of mammalian erythrocytes: chromatin condensation and enucleation |
| title_sort | formation of mammalian erythrocytes chromatin condensation and enucleation |
| url | http://hdl.handle.net/1721.1/99166 https://orcid.org/0000-0002-7029-7415 |
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