Biological hydrogels as selective diffusion barriers
The controlled exchange of molecules between organelles, cells, or organisms and their environment is crucial for life. Biological gels such as mucus, the extracellular matrix (ECM), and the biopolymer barrier within the nuclear pore are well suited to achieve such a selective exchange, allowing pas...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/99190 https://orcid.org/0000-0001-8260-338X |
| _version_ | 1811072612872224768 |
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| author | Lieleg, Oliver Ribbeck, Katharina |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Lieleg, Oliver Ribbeck, Katharina |
| author_sort | Lieleg, Oliver |
| collection | MIT |
| description | The controlled exchange of molecules between organelles, cells, or organisms and their environment is crucial for life. Biological gels such as mucus, the extracellular matrix (ECM), and the biopolymer barrier within the nuclear pore are well suited to achieve such a selective exchange, allowing passage of particular molecules while rejecting many others. Although hydrogel-based filters are integral parts of biology, clear concepts of how their barrier function is controlled at a microscopic level are still missing. We summarize here our current understanding of how selective filtering is established by different biopolymer-based hydrogels. We ask if the modulation of microscopic particle transport in biological hydrogels is based on a generic filtering principle which employs biochemical/biophysical interactions with the filtered molecules rather than size-exclusion effects. |
| first_indexed | 2024-09-23T09:08:48Z |
| format | Article |
| id | mit-1721.1/99190 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:08:48Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/991902022-09-30T13:45:02Z Biological hydrogels as selective diffusion barriers Lieleg, Oliver Ribbeck, Katharina Massachusetts Institute of Technology. Department of Biological Engineering Lieleg, Oliver Ribbeck, Katharina The controlled exchange of molecules between organelles, cells, or organisms and their environment is crucial for life. Biological gels such as mucus, the extracellular matrix (ECM), and the biopolymer barrier within the nuclear pore are well suited to achieve such a selective exchange, allowing passage of particular molecules while rejecting many others. Although hydrogel-based filters are integral parts of biology, clear concepts of how their barrier function is controlled at a microscopic level are still missing. We summarize here our current understanding of how selective filtering is established by different biopolymer-based hydrogels. We ask if the modulation of microscopic particle transport in biological hydrogels is based on a generic filtering principle which employs biochemical/biophysical interactions with the filtered molecules rather than size-exclusion effects. National Institutes of Health (U.S.) (Grant P50GM068763) MIT Start-up Funds German Academic Exchange Service (Postdoctoral Fellowship) 2015-10-07T16:43:30Z 2015-10-07T16:43:30Z 2011-07 Article http://purl.org/eprint/type/JournalArticle 09628924 http://hdl.handle.net/1721.1/99190 Lieleg, Oliver, and Katharina Ribbeck. “Biological Hydrogels as Selective Diffusion Barriers.” Trends in Cell Biology 21, no. 9 (September 2011): 543–551. https://orcid.org/0000-0001-8260-338X en_US http://dx.doi.org/10.1016/j.tcb.2011.06.002 Trends in Cell Biology Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Lieleg, Oliver Ribbeck, Katharina Biological hydrogels as selective diffusion barriers |
| title | Biological hydrogels as selective diffusion barriers |
| title_full | Biological hydrogels as selective diffusion barriers |
| title_fullStr | Biological hydrogels as selective diffusion barriers |
| title_full_unstemmed | Biological hydrogels as selective diffusion barriers |
| title_short | Biological hydrogels as selective diffusion barriers |
| title_sort | biological hydrogels as selective diffusion barriers |
| url | http://hdl.handle.net/1721.1/99190 https://orcid.org/0000-0001-8260-338X |
| work_keys_str_mv | AT lielegoliver biologicalhydrogelsasselectivediffusionbarriers AT ribbeckkatharina biologicalhydrogelsasselectivediffusionbarriers |