Tuning adhesion failure strength for tissue-specific applications
Soft tissue adhesives are employed to repair and seal many different organs, which range in both tissue surface chemistry and mechanical challenges during organ function. This complexity motivates the development of tunable adhesive materials with high resistance to uniaxial or multiaxial loads dict...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/99200 https://orcid.org/0000-0001-5735-0560 https://orcid.org/0000-0002-7832-7156 |
| _version_ | 1826198587602632704 |
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| author | Artzi, Natalie Zeiger, Adam Boehning, Fiete bon Ramos, Adriana Edelman, Elazer R. Van Vliet, Krystyn J. |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Artzi, Natalie Zeiger, Adam Boehning, Fiete bon Ramos, Adriana Edelman, Elazer R. Van Vliet, Krystyn J. |
| author_sort | Artzi, Natalie |
| collection | MIT |
| description | Soft tissue adhesives are employed to repair and seal many different organs, which range in both tissue surface chemistry and mechanical challenges during organ function. This complexity motivates the development of tunable adhesive materials with high resistance to uniaxial or multiaxial loads dictated by a specific organ environment. Co-polymeric hydrogels comprising aminated star polyethylene glycol and dextran aldehyde (PEG:dextran) are materials exhibiting physico-chemical properties that can be modified to achieve this organ- and tissue-specific adhesion performance. Here we report that resistance to failure under specific loading conditions, as well as tissue response at the adhesive material–tissue interface, can be modulated through regulation of the number and density of adhesive aldehyde groups. We find that atomic force microscopy (AFM) can characterize the material aldehyde density available for tissue interaction, and in this way enable rapid, informed material choice. Further, the correlation between AFM quantification of nanoscale unbinding forces with macroscale measurements of adhesion strength by uniaxial tension or multiaxial burst pressure allows the design of materials with specific cohesion and adhesion strengths. However, failure strength alone does not predict optimal in vivo reactivity. Thus, we demonstrate that the development of adhesive materials is significantly enabled when experiments are integrated along length scales to consider organ chemistry and mechanical loading states concurrently with adhesive material properties and tissue response. |
| first_indexed | 2024-09-23T11:07:09Z |
| format | Article |
| id | mit-1721.1/99200 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:07:09Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/992002022-09-27T17:14:56Z Tuning adhesion failure strength for tissue-specific applications Artzi, Natalie Zeiger, Adam Boehning, Fiete bon Ramos, Adriana Edelman, Elazer R. Van Vliet, Krystyn J. Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Materials Science and Engineering Artzi, Natalie Zeiger, Adam Boehning, Fiete bon Ramos, Adriana Van Vliet, Krystyn J. Edelman, Elazer R. Soft tissue adhesives are employed to repair and seal many different organs, which range in both tissue surface chemistry and mechanical challenges during organ function. This complexity motivates the development of tunable adhesive materials with high resistance to uniaxial or multiaxial loads dictated by a specific organ environment. Co-polymeric hydrogels comprising aminated star polyethylene glycol and dextran aldehyde (PEG:dextran) are materials exhibiting physico-chemical properties that can be modified to achieve this organ- and tissue-specific adhesion performance. Here we report that resistance to failure under specific loading conditions, as well as tissue response at the adhesive material–tissue interface, can be modulated through regulation of the number and density of adhesive aldehyde groups. We find that atomic force microscopy (AFM) can characterize the material aldehyde density available for tissue interaction, and in this way enable rapid, informed material choice. Further, the correlation between AFM quantification of nanoscale unbinding forces with macroscale measurements of adhesion strength by uniaxial tension or multiaxial burst pressure allows the design of materials with specific cohesion and adhesion strengths. However, failure strength alone does not predict optimal in vivo reactivity. Thus, we demonstrate that the development of adhesive materials is significantly enabled when experiments are integrated along length scales to consider organ chemistry and mechanical loading states concurrently with adhesive material properties and tissue response. National Science Foundation (U.S.) (Career Award) American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowship National Institutes of Health (U.S.) (Grant ERE GM 49039) 2015-10-08T13:04:22Z 2015-10-08T13:04:22Z 2010-07 2010-06 Article http://purl.org/eprint/type/JournalArticle 17427061 http://hdl.handle.net/1721.1/99200 Artzi, Natalie, Adam Zeiger, Fiete Boehning, Adriana bon Ramos, Krystyn Van Vliet, and Elazer R. Edelman. “Tuning Adhesion Failure Strength for Tissue-Specific Applications.” Acta Biomaterialia 7, no. 1 (January 2011): 67–74. https://orcid.org/0000-0001-5735-0560 https://orcid.org/0000-0002-7832-7156 en_US http://dx.doi.org/10.1016/j.actbio.2010.07.008 Acta Biomaterialia Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Artzi, Natalie Zeiger, Adam Boehning, Fiete bon Ramos, Adriana Edelman, Elazer R. Van Vliet, Krystyn J. Tuning adhesion failure strength for tissue-specific applications |
| title | Tuning adhesion failure strength for tissue-specific applications |
| title_full | Tuning adhesion failure strength for tissue-specific applications |
| title_fullStr | Tuning adhesion failure strength for tissue-specific applications |
| title_full_unstemmed | Tuning adhesion failure strength for tissue-specific applications |
| title_short | Tuning adhesion failure strength for tissue-specific applications |
| title_sort | tuning adhesion failure strength for tissue specific applications |
| url | http://hdl.handle.net/1721.1/99200 https://orcid.org/0000-0001-5735-0560 https://orcid.org/0000-0002-7832-7156 |
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