‘Hygienic’ Lymphocytes Convey Increased Cancer Risk
Risk of developing inflammation-associated cancers has increased in industrialized countries during the past 30 years. One possible explanation is societal hygiene practices with use of antibiotics and Caesarian births that provide too few early life exposures of beneficial microbes. Building upon a...
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| Format: | Article |
| Language: | en_US |
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Lifescience Global
2015
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| Online Access: | http://hdl.handle.net/1721.1/99236 https://orcid.org/0000-0001-8294-9364 https://orcid.org/0000-0003-4700-5987 https://orcid.org/0000-0003-4378-9542 |
| _version_ | 1826204542332567552 |
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| author | Levkovich, Tatiana Poutahidis, Theofilos Cappelle, Kelsey Smith, Mark Burnham Perrotta, Allison Rose Alm, Eric J. Erdman, Susan E. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Levkovich, Tatiana Poutahidis, Theofilos Cappelle, Kelsey Smith, Mark Burnham Perrotta, Allison Rose Alm, Eric J. Erdman, Susan E. |
| author_sort | Levkovich, Tatiana |
| collection | MIT |
| description | Risk of developing inflammation-associated cancers has increased in industrialized countries during the past 30 years. One possible explanation is societal hygiene practices with use of antibiotics and Caesarian births that provide too few early life exposures of beneficial microbes. Building upon a ‘hygiene hypothesis’ model whereby prior microbial exposures lead to beneficial changes in CD4+ lymphocytes, here we use an adoptive cell transfer model and find that too few prior microbe exposures alternatively result in increased inflammation-associated cancer growth in susceptible recipient mice. Specifically, purified CD4+ lymphocytes collected from ‘restricted flora’ donors increases multiplicity and features of malignancy in intestinal polyps of recipient Apc[superscript Min/+] mice, coincident with increased inflammatory cell infiltrates and instability of the intestinal microbiota. We conclude that while a competent immune system serves to maintain intestinal homeostasis and good health, under hygienic rearing conditions CD4+ lymphocytes instead exacerbate inflammation-associated tumorigenesis, subsequently contributing to more frequent cancers in industrialized societies. |
| first_indexed | 2024-09-23T12:57:08Z |
| format | Article |
| id | mit-1721.1/99236 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:57:08Z |
| publishDate | 2015 |
| publisher | Lifescience Global |
| record_format | dspace |
| spelling | mit-1721.1/992362022-09-28T11:04:32Z ‘Hygienic’ Lymphocytes Convey Increased Cancer Risk Levkovich, Tatiana Poutahidis, Theofilos Cappelle, Kelsey Smith, Mark Burnham Perrotta, Allison Rose Alm, Eric J. Erdman, Susan E. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Levkovich, Tatiana Poutahidis, Theofilos Cappelle, Kelsey Smith, Mark Burnham Perrotta, Allison Rose Alm, Eric J. Erdman, Susan E. Risk of developing inflammation-associated cancers has increased in industrialized countries during the past 30 years. One possible explanation is societal hygiene practices with use of antibiotics and Caesarian births that provide too few early life exposures of beneficial microbes. Building upon a ‘hygiene hypothesis’ model whereby prior microbial exposures lead to beneficial changes in CD4+ lymphocytes, here we use an adoptive cell transfer model and find that too few prior microbe exposures alternatively result in increased inflammation-associated cancer growth in susceptible recipient mice. Specifically, purified CD4+ lymphocytes collected from ‘restricted flora’ donors increases multiplicity and features of malignancy in intestinal polyps of recipient Apc[superscript Min/+] mice, coincident with increased inflammatory cell infiltrates and instability of the intestinal microbiota. We conclude that while a competent immune system serves to maintain intestinal homeostasis and good health, under hygienic rearing conditions CD4+ lymphocytes instead exacerbate inflammation-associated tumorigenesis, subsequently contributing to more frequent cancers in industrialized societies. National Institutes of Health (U.S.) (Grant P30-ES002109) National Institutes of Health (U.S.) (Grant U01 CA164337) National Institutes of Health (U.S.) (Grant RO1CA108854) 2015-10-13T19:02:57Z 2015-10-13T19:02:57Z 2014-08 Article http://purl.org/eprint/type/JournalArticle 19277229 http://hdl.handle.net/1721.1/99236 Erdman, Susan, Tatiana Levkovich, Theofilos Poutahidis, Kelsey Cappelle, Mark Smith, Allison Perrotta, and Eric Alm. “‘Hygienic’ Lymphocytes Convey Increased Cancer Risk.” Journal of Analytical Oncology 3, no. 3 (August 12, 2014): 113–121. https://orcid.org/0000-0001-8294-9364 https://orcid.org/0000-0003-4700-5987 https://orcid.org/0000-0003-4378-9542 en_US http://dx.doi.org/10.6000/1927-7229.2014.03.03.1 Journal of Analytical Oncology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Lifescience Global PMC |
| spellingShingle | Levkovich, Tatiana Poutahidis, Theofilos Cappelle, Kelsey Smith, Mark Burnham Perrotta, Allison Rose Alm, Eric J. Erdman, Susan E. ‘Hygienic’ Lymphocytes Convey Increased Cancer Risk |
| title | ‘Hygienic’ Lymphocytes Convey Increased Cancer Risk |
| title_full | ‘Hygienic’ Lymphocytes Convey Increased Cancer Risk |
| title_fullStr | ‘Hygienic’ Lymphocytes Convey Increased Cancer Risk |
| title_full_unstemmed | ‘Hygienic’ Lymphocytes Convey Increased Cancer Risk |
| title_short | ‘Hygienic’ Lymphocytes Convey Increased Cancer Risk |
| title_sort | hygienic lymphocytes convey increased cancer risk |
| url | http://hdl.handle.net/1721.1/99236 https://orcid.org/0000-0001-8294-9364 https://orcid.org/0000-0003-4700-5987 https://orcid.org/0000-0003-4378-9542 |
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