Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models
Since its discovery in 1982, the global importance of Helicobacter pylori–induced disease, particularly in developing countries, remains high. The use of rodent models, particularly mice, and the unanticipated usefulness of the gerbil to study H. pylori pathogenesis have been used extensively to stu...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Sage Publications
2015
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| Online Access: | http://hdl.handle.net/1721.1/99368 https://orcid.org/0000-0001-9307-6116 |
| _version_ | 1811072716814417920 |
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| author | Fox, James G. Wang, Timothy C. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Fox, James G. Wang, Timothy C. |
| author_sort | Fox, James G. |
| collection | MIT |
| description | Since its discovery in 1982, the global importance of Helicobacter pylori–induced disease, particularly in developing countries, remains high. The use of rodent models, particularly mice, and the unanticipated usefulness of the gerbil to study H. pylori pathogenesis have been used extensively to study the interactions of the host, the pathogen, and the environmental conditions influencing the outcome of persistent H. pylori infection. Dietary factors in humans are increasingly recognized as being important factors in modulating progression and severity of H. pylori–induced gastric cancer. Studies using rodent models to verify and help explain mechanisms whereby various dietary ingredients impact disease outcome should continue to be extremely productive. |
| first_indexed | 2024-09-23T09:10:53Z |
| format | Article |
| id | mit-1721.1/99368 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:10:53Z |
| publishDate | 2015 |
| publisher | Sage Publications |
| record_format | dspace |
| spelling | mit-1721.1/993682022-09-26T10:56:50Z Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models Fox, James G. Wang, Timothy C. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Fox, James G. Since its discovery in 1982, the global importance of Helicobacter pylori–induced disease, particularly in developing countries, remains high. The use of rodent models, particularly mice, and the unanticipated usefulness of the gerbil to study H. pylori pathogenesis have been used extensively to study the interactions of the host, the pathogen, and the environmental conditions influencing the outcome of persistent H. pylori infection. Dietary factors in humans are increasingly recognized as being important factors in modulating progression and severity of H. pylori–induced gastric cancer. Studies using rodent models to verify and help explain mechanisms whereby various dietary ingredients impact disease outcome should continue to be extremely productive. National Institutes of Health (U.S.) (P01CA028842) National Institutes of Health (U.S.) (P01CA026731) National Institutes of Health (U.S.) (P30ES002109) 2015-10-20T12:41:07Z 2015-10-20T12:41:07Z 2013-12 Article http://purl.org/eprint/type/JournalArticle 0192-6233 1533-1601 http://hdl.handle.net/1721.1/99368 Fox, J. G., and T. C. Wang. “Dietary Factors Modulate Helicobacter-Associated Gastric Cancer in Rodent Models.” Toxicologic Pathology 42, no. 1 (December 3, 2013): 162–181. https://orcid.org/0000-0001-9307-6116 en_US http://dx.doi.org/10.1177/0192623313512564 Toxicologic Pathology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Sage Publications PMC |
| spellingShingle | Fox, James G. Wang, Timothy C. Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models |
| title | Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models |
| title_full | Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models |
| title_fullStr | Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models |
| title_full_unstemmed | Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models |
| title_short | Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models |
| title_sort | dietary factors modulate helicobacter associated gastric cancer in rodent models |
| url | http://hdl.handle.net/1721.1/99368 https://orcid.org/0000-0001-9307-6116 |
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