Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

Background & Aims Interleukin (IL)-8 has an important role in initiating inflammation in humans, attracting immune cells such as neutrophils through their receptors CXCR1 and CXCR2. IL-8 has been proposed to contribute to chronic inflammation and cancer. However, mice do not have the IL-8 gene,...

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Bibliographic Details
Main Authors: Asfaha, Samuel, Dubeykovskiy, Alexander N., Tomita, Hiroyuki, Yang, Xiangdong, Stokes, Sarah, Shibata, Wataru, Friedman, Richard A., Ariyama, Hiroshi, Dubeykovskaya, Zinaida A., Muthupalani, Sureshkumar, Ericksen, Russell, Frucht, Harold, Fox, James G., Wang, Timothy C.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/99370
https://orcid.org/0000-0001-9307-6116

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