Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting
A novel linear-dendritic block copolymer has been synthesized and evaluated for targeted delivery. The use of the dendron as the micellar exterior block in this architecture allows the presentation of a relatively small quantity of ligands in clusters for enhanced targeting, thus maintaining a long...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/99388 |
| _version_ | 1826205411486728192 |
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| author | Poon, Zhiyong Lee, Jung Ah Huang, Shenwen Prevost, Richard J. Hammond, Paula T. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Poon, Zhiyong Lee, Jung Ah Huang, Shenwen Prevost, Richard J. Hammond, Paula T. |
| author_sort | Poon, Zhiyong |
| collection | MIT |
| description | A novel linear-dendritic block copolymer has been synthesized and evaluated for targeted delivery. The use of the dendron as the micellar exterior block in this architecture allows the presentation of a relatively small quantity of ligands in clusters for enhanced targeting, thus maintaining a long circulation time of these “patchy” micelles. The polypeptide linear hydrophobic block drives formation of micelles that carry core-loaded drugs, and their unique design gives them extremely high stability in vivo. We have found that these systems lead to extended time periods of increased accumulation in the tumor (up to 5 days) compared with nontargeted vehicles. We also demonstrate a fourfold increase in efficacy of paclitaxel when delivered in the targeted nanoparticle systems, while significantly decreasing in vivo toxicity of the chemotherapy treatment. |
| first_indexed | 2024-09-23T13:12:16Z |
| format | Article |
| id | mit-1721.1/99388 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:12:16Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/993882022-10-01T13:43:43Z Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting Poon, Zhiyong Lee, Jung Ah Huang, Shenwen Prevost, Richard J. Hammond, Paula T. Massachusetts Institute of Technology. Department of Chemical Engineering Poon, Zhiyong Lee, Jung Ah Huang, Shenwen Prevost, Richard J. Hammond, Paula T. A novel linear-dendritic block copolymer has been synthesized and evaluated for targeted delivery. The use of the dendron as the micellar exterior block in this architecture allows the presentation of a relatively small quantity of ligands in clusters for enhanced targeting, thus maintaining a long circulation time of these “patchy” micelles. The polypeptide linear hydrophobic block drives formation of micelles that carry core-loaded drugs, and their unique design gives them extremely high stability in vivo. We have found that these systems lead to extended time periods of increased accumulation in the tumor (up to 5 days) compared with nontargeted vehicles. We also demonstrate a fourfold increase in efficacy of paclitaxel when delivered in the targeted nanoparticle systems, while significantly decreasing in vivo toxicity of the chemotherapy treatment. National Institute for Biomedical Imaging and Bioengineering (U.S.) National Cancer Institute (U.S.) (R01EB008082-01A2) 2015-10-21T15:13:02Z 2015-10-21T15:13:02Z 2010-09 2010-07 Article http://purl.org/eprint/type/JournalArticle 15499634 http://hdl.handle.net/1721.1/99388 Poon, Zhiyong, Jung Ah Lee, Shenwen Huang, Richard J. Prevost, and Paula T. Hammond. “Highly Stable, Ligand-Clustered ‘patchy’ Micelle Nanocarriers for Systemic Tumor Targeting.” Nanomedicine: Nanotechnology, Biology and Medicine 7, no. 2 (April 2011): 201–209. en_US http://dx.doi.org/10.1016/j.nano.2010.07.008 Nanomedicine: Nanotechnology, Biology and Medicine Creative Commons Attribution-Noncommercial-NoDerivatives http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Poon, Zhiyong Lee, Jung Ah Huang, Shenwen Prevost, Richard J. Hammond, Paula T. Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting |
| title | Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting |
| title_full | Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting |
| title_fullStr | Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting |
| title_full_unstemmed | Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting |
| title_short | Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting |
| title_sort | highly stable ligand clustered patchy micelle nanocarriers for systemic tumor targeting |
| url | http://hdl.handle.net/1721.1/99388 |
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