Optimization of [superscript 13]C isotopic tracers for metabolic flux analysis in mammalian cells

Optimization of [superscript 13]C isotopic tracers for metabolic flux analysis in mammalian cells

Mammalian cells consume and metabolize various substrates from their surroundings for energy generation and biomass synthesis. Glucose and glutamine, in particular, are the primary carbon sources for proliferating cancer cells. While this combination of substrates generates static labeling patterns...

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Bibliographic Details
Main Authors:	Walther, Jason L., Metallo, Christian M., Zhang, Jie, Stephanopoulos, Gregory
Other Authors:	Massachusetts Institute of Technology. Department of Chemical Engineering
Format:	Article
Language:	en_US
Published:	Elsevier 2015
Online Access:	http://hdl.handle.net/1721.1/99396 https://orcid.org/0000-0001-6909-4568

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