Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury

Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury

The efficacy of biological therapeutics against cartilage degradation in osteoarthritis is restricted by the limited transport of macromolecules through the dense, avascular extracellular matrix. The availability of biologics to cell surface and matrix targets is limited by steric hindrance of the m...

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Bibliographic Details
Main Authors:	Byun, Sangwon, Sinskey, Yunna L., Lu, Yihong C. S., Ort, Tatiana, Kavalkovich, Karl, Sivakumar, Pitchumani, Hunziker, Ernst B., Grodzinsky, Alan J., Frank, Eliot
Other Authors:	Massachusetts Institute of Technology. Center for Biomedical Engineering
Format:	Article
Language:	en_US
Published:	Elsevier 2015
Online Access:	http://hdl.handle.net/1721.1/99412 https://orcid.org/0000-0002-4942-3456

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